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Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices.
TLDR
There was a large variation in the rate of decline of different CYP levels with time in culture, and there was also a large difference in the stability of individual CYP enzymes from different liver donors, particularly for the most rapidly declining CyP enzymes. Expand
Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices.
TLDR
The utility of cultured human liver slices for assessing the effects of chemicals on P450 enzymes is demonstrated, and levels of CYP1A1 apoprotein were not detected in any liver slice sample, either before or after treatment with the model inducers. Expand
Thiopurine methyltransferase phenotype and genotype in relation to azathioprine therapy in autoimmune hepatitis.
TLDR
TPMT phenotyping or genotyping may be advisable before institution of azathioprine therapy in AIH but neither approach invariably predicts response to the drug. Expand
Coagulation factor V and VIII/V ratio as predictors of outcome in paracetamol induced fulminant hepatic failure: relation to other prognostic indicators.
TLDR
Predictive accuracy was 73% and 82% for factor V and admission acidosis respectively and 95% for factors V in conjunction with admission coma grade III or IV and factor VIII (ratio > 30), which may be useful in selecting patients with fulminant hepatic failure for transplantation. Expand
Monitoring mycophenolate in liver transplant recipients: Toward a therapeutic range
TLDR
The data suggests that MPA predose level monitoring is both clinically‐ and cost‐effective and that a therapeutic range of 1 to 3.5mg/L (by immunoassay) is applicable in liver allograft recipients given adjunctive MMF. Expand
The effect of tacrolimus (FK506) on intestinal barrier function and cellular energy production in humans.
TLDR
Tacrolimus inhibited the decarboxylation of [13C]KICA, the resting energy expenditure, and the respiratory quotient in an exposure-dependent manner, suggesting an inhibition of mitochondrial respiration. Expand
Contribution of true cold and rewarming ischemia times to factors determining outcome after orthotopic liver transplantation.
TLDR
In the small number of patients with a WIT of greater than 180 minutes, there were reductions in graft survival but these just failed to reach significance (P = .055). Expand
Antioxidant properties of S-adenosyl-L-methionine: a proposed addition to organ storage fluids.
TLDR
Alternative sulphur-containing compounds such as S-adenosyl-L-methionine (SAM) can reduce ischaemia-reperfusion injury, possibly by acting as glutathione precursors, and are effective when added to preservation solutions, and could include direct radical scavenging as a precursor for intracellular GSH. Expand
Catalytic metal ions and the loss of reduced glutathione from University of Wisconsin preservation solution.
TLDR
It is shown that this fluid is often contaminated by traces of iron catalytic for free radical reactions, as demonstrated by the bleomycin assay and the ability of the iron to stimulate lipid peroxidation induced by the contaminant iron in the preservation solution. Expand
Hepatotoxicity to sodium valproate: a review.
TLDR
This review has analysed the 42 cases with fatal hepatitis either known to the manufacturers or reported elsewhere, and the more frequent cases with milder forms of hepatitis varying in severity from a transient rise in aminotransferase activities to symptomatic cases with reversible hepatic failure. Expand
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