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Effects of 5-lipoxygenase inhibition on cardiac anaphylaxis in isolated guinea pig hearts.
Results provide further evidence for the contribution of leukotrienes to cardiac anaphylaxis and suggest that 5-lipoxygenase inhibitors can be beneficial in situations where endogenous leukOTrienes produce coronary vasoconstriction and myocardial depression.
Assessment of the clinical cardiac drug‐drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys
These are the first preclinical in vivo experiments reported to replicate the severe clinical SOF+AMIO cardiac DDI and provide potential in vivo mechanism of action, and suggest that not all HCV DAAs and, in particular, not allHCV nonstructural protein 5B inhibitors may exhibit this cardiac D DI with amiodarone.
Effect of RG 12525 on pulmonary function in sensitized and non sensitized guinea pigs challenged with leukotriene D4 (LTD4)
The inhibition of 5-lipoxygenase by RG 6866
Findings indicate that RG 6866 is an inhibitor of 5-LOX both in vitro and in vivo, and in actively sensitized guinea pigs pretreated with indomethacin, propranolol and pyrilamine.
The effect of RG 12525 on leukotriene D4-mediated pulmonary responses in guinea pigs
Data indicate that RG 12525 is a potent, orally active LTD4 antagonist which possesses the requisite profile for potential clinical development.