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Distinct clinical phenotypes of airways disease defined by cluster analysis
TLDR
Five distinct clinical phenotypes of airflow obstruction were identified and may form the basis of a modified taxonomy for the disorders of airways obstruction in a community population with airways disease. Expand
Reference ranges for exhaled nitric oxide derived from a random community survey of adults.
TLDR
Measurement of Fe(NO) had poor discriminant ability to identify steroid-naive subjects with asthma and several reference ranges are presented adjusting for these factors. Expand
Proportional classifications of COPD phenotypes
TLDR
This study provides proportional classifications of the phenotypic subgroups of COPD which can be used as the basis for further research into the pathogenesis and treatment of this heterogeneous disorder. Expand
External validity of randomized controlled trials in COPD.
TLDR
From a respiratory health survey of adults randomly selected from the community, the proportion of subjects with COPD who would have been eligible for inclusion in major COPD RCTs is estimated, finding over 90% of the COPD subjects in the community who were taking medication did so on the basis of R CTs for which they would not have been ineligible. Expand
Use of cluster analysis to define COPD phenotypes
TLDR
Cluster analysis is a collection of methods for defining groups of individuals based on measured characteristics, so that they are grouped based on their differences (or similarities) into clusters, into clusters. Expand
COPD prevalence in a random population survey: a matter of definition
TLDR
The prevalence of chronic obstructive pulmonary disease varied markedly depending on the definition used, with the GOLD-defined, age-adjusted prevalence (95% confidence interval) for adults aged ≥40 yrs was 14.2 (11.0–17.0)% compared with an LLN- defined, Age-adjusted, post-bronchodilator prevalence in the same group of 9.0 (6.7–11.3)%. Expand
Reliability of ventilatory parameters during cycle ergometry in multicentre trials in COPD
TLDR
Key perceptual and ventilatory parameters can be reliably measured during CWR cycle exercise in multicentre clinical trials in moderate to very severe COPD. Expand
The multiple dimensions of airways disease: targeting treatment to clinical phenotypes
TLDR
The priority is to further define the distinct phenotypes that make up the syndromes of asthma and COPD, which could lead to treatments specifically targeted for defined phenotypic groups, rather than for asthma and CopD in general, which represents the current management approach. Expand
Quality of life measured by the St George's Respiratory Questionnaire and spirometry
TLDR
There may be advantages in using forced expiratory volume in one second cut-off points of 80, 60 and 40% predicted for the classification of mild, moderate and severe chronic obstructive pulmonary disease, respectively, similar to the approach recommended for asthma. Expand
Childhood asthma and GOLD‐defined chronic obstructive pulmonary disease
TLDR
This study aimed to investigate the strength of association of various known risk factors for COPD by examining the interaction of genetic and environmental factors. Expand
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