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Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential
Peptide fragments of PEDF carry biological activity and may be valuable therapeutic agents that readily penetrate the eye and can inhibit the growth of blood vessels in the eye induced in a variety of ways. Expand
Novel mechanism for age‐related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF
Analysis of gene expression profiles of vascular endothelial growth factor (VEGF) and pigment epithelium‐derived factor (PEDF) in differentiated and non‐differentiated retinal pigment epithelial (RPE) cells during oxidative stress suggests that, in physiological conditions, a critical balance between PEDF and VEGF exists, and PEDf may counteract the angiogenic potential of V EGF. Expand
Osteoblasts and osteoclasts express PEDF, VEGF-A isoforms, and VEGF receptors: possible mediators of angiogenesis and matrix remodeling in the bone.
The localization of PEDF in regions of active bone formation in the mid-gestation mouse embryo and its specific and high levels of secretion by osteoblasts suggest that bone angiogenesis and matrix remodeling may be mediated both by PEDf and by VEGF. Expand
PEDF: a multifaceted neurotrophic factor
The structure and function of PEDF and the biochemical pathways it activates are discussed, and ways in which this molecule might become a valuable therapeutic agent are suggested. Expand
Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family.
PEDF could exert a paracrine effect in the embryonic retina, influencing neuronal differentiation by a mechanism that does not involve classic inhibition of serine protease activity. Expand
Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity
Evidence is provided that the gene for pigment epithelium-derived factor (PEDF), a protein possessing neurotrophic and neuronal-survival activities, is highly expressed by both fetal and young adult RPE cells, and is apparently present intracellularly and extracellularly inBoth fetal and early adult periods where it could be involved in cellular differentiation and survival and with its loss, in the onset of senescence. Expand
Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells.
The response of Y79 cells to RPE-conditioned medium indicates that factors secreted by RPE cells can act as inducers of neuronal differentiation in retinoblastoma cells and suggest that such factors may be of importance in the development and differentiation of the neural retina. Expand
Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration.
It is hypothesized that PEDF may play important roles in the survival and maintenance of spinal motor neurons in their neuroprotection against acquired insults in postnatal life and should be developed further as a therapeutic strategy for motor neuron diseases such as ALS. Expand
Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants.
  • Yuan He, K. Leung, +6 authors J. Ge
  • Biology, Medicine
  • Investigative ophthalmology & visual science
  • 1 April 2008
It is proposed that a mitochondrial complex I defect is associated with the degeneration of TM cells in patients with POAG, and antioxidants and MPT inhibitors can reduce the progression of this condition. Expand