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Pulmonary pathology of acute respiratory distress syndrome.
  • J. Tomashefski
  • Medicine, Biology
    Clinics in chest medicine
  • 1 September 2000
The pulmonary vascular lesions of the adult respiratory distress syndrome.
TLDR
Peripheral extension of vascular smooth muscle and a significant increase in the percentage of medial thickness of muscular arteries with duration of ARDS were noted and the pathogenesis and clinical significance of these lesions is discussed.
Morphometric analysis of the lung in bronchopulmonary dysplasia.
TLDR
It is concluded that in severe, fatal BPD there is marked impairment of lung development with alveolar hypoplasia and reduced internal surface area, andBronchial and bronchiolar smooth muscle hypertrophy and Bronchial gland hyperplasia may be important contributing factors to airflow limitation.
Nontuberculous mycobacteria. II: nested-cohort study of impact on cystic fibrosis lung disease.
TLDR
No significant short-term effect on FEV1 was detected in patients with multiple positive NTM cultures, but an abnormal HRCT was predictive of progression, which should be monitored closely and considered for antimycobacterial therapy.
Infant animal model of pulmonary mycotoxicosis induced by Stachybotrys chartarum
TLDR
An infant rat model of stachybotrytoxicosis describing the effects of fungal spores on survival, growth, histopathology of the lung and respiration and extracted spores had a minimal effect on all examined parameters in BAL fluid indicating that mycotoxins are primarily responsible for the hemorrhagic and inflammatory response.
Pulmonary pathology of the adult respiratory distress syndrome.
  • J. Tomashefski
  • Medicine, Biology
    Clinics in chest medicine
  • 1 December 1990
TLDR
It is suggested that there is a spectrum in the extent of lung involvement and disease severity in patients at risk for ARDS, and the factors that govern which patients will develop the fulminant syndrome are poorly understood.
Surfactant protein deficiency in familial interstitial lung disease.
TLDR
The apparent absence ofSP-C and a decrease in the levels of SP-A and SP-B are associated with familial interstitial lung disease.
Disordered Toll‐like receptor 2 responses in the pathogenesis of pulmonary sarcoidosis
TLDR
The findings support a potential role for disordered TLR‐2 responses in the pathogenesis of pulmonary sarcoidosis and evaluated the impact of TLR-2 gene deletion in a recently described murine model of T helper type 1 (Th1)‐associated lung disease induced by heat‐killed Propionibacterium acnes.
Mortality in individuals with severe deficiency of alpha1-antitrypsin: findings from the National Heart, Lung, and Blood Institute Registry.
TLDR
It is concluded that severe AAT deficiency poses a significant threat to health, that severe airflow obstruction is a major determinant of mortality, and that liver and lung disease account for the excess mortality in affected individuals.
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