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Expression of Cholesteryl Ester Transfer Protein in Mice Promotes Macrophage Reverse Cholesterol Transport
TLDR
CETP expression promotes macrophage RCT in mice, that this effect is dependent on the low-density lipoprotein receptor, and that CETP expression restores to normal the impaired R CT in mice deficient in scavenger receptor class B, type I. Expand
A mutation in the saposin A domain of the sphingolipid activator protein (prosaposin) gene results in a late-onset, chronic form of globoid cell leukodystrophy in the mouse.
TLDR
Saposin A is indispensable for in vivo degradation of galactosylceramide by GALC, and genetic saposin A deficiency could also cause chronic GLD. Expand
Knockout of Adamts7, a Novel Coronary Artery Disease Locus in Humans, Reduces Atherosclerosis in Mice
TLDR
It is demonstrated that Adamts7 is proatherogenic, lending directionality to the original genetic association and supporting the concept that pharmacological inhibition of ADAMTS7 should be atheroprotective in humans, making it an attractive target for novel therapeutic interventions. Expand
Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis.
TLDR
Macrophage sortilin deficiency protects against atherosclerosis by reducing macrophage uptake of LDL andSortilin-mediated uptake of native LDL into macrophages may be an important mechanism of foam cell formation and contributor to Atherosclerosis development. Expand
Genetic Ablation of Adamts13 Gene Dramatically Accelerates the Formation of Early Atherosclerosis in a Murine Model
TLDR
The results suggest that ADAMTS13 plays a critical role in modulating the development of early atherosclerosis, likely through the proteolytic cleavage of ultra-large von Willebrand factor multimers, thereby inhibiting platelet deposition and inflammation. Expand
A novel two nucleotide deletion in the apolipoprotein A-I gene, apoA-I Shinbashi, associated with high density lipoprotein deficiency, corneal opacities, planar xanthomas, and premature coronary
TLDR
A novel genetic variant of the apolipoprotein A-I (apoA-I) gene resulting in FHD is described, believed to be the first case involving a single gene defect to develop all the characteristics for apoA- I deficiency, including premature coronary heart disease. Expand
Evidence for active acetylcholine metabolism in human amniotic epithelial cells: applicable to intracerebral allografting for neurologic disease
TLDR
Results of the present study suggest that HAE cells can possibly be applied for intracerebral allografting to treat neurologic diseases in which cholinergic neurons are damaged. Expand
Lecithin: Cholesterol Acyltransferase Expression Has Minimal Effects on Macrophage Reverse Cholesterol Transport In Vivo
TLDR
Although LCAT activity does become rate limiting in the context of complete LCAT deficiency, RCT is reduced by only 50% even in the absence of LCAT, suggesting that macrophage RCT may not be as dependent onLCAT activity as has previously been believed. Expand
Fenofibrate effectively reduces remnants, and small dense LDL, and increases HDL particle number in hypertriglyceridemic men - a nuclear magnetic resonance study.
TLDR
Fenofibrate effectively improves atherogenic dyslipidemia by reducing remnants and small LDL, as well as by increasing HDL particles, which might provide a clinical benefit in hypertriglyceridemic subjects. Expand
Increased Protein Nitration Burden in the Atherosclerotic Lesions and Plasma of Apolipoprotein A-I–Deficient Mice
TLDR
Data collectively support a protective function of apoA-I diminishing the burden of nitrative oxidants in these mice models of atherosclerosis. Expand
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