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Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma
The relation between viremia and clinical outcome in individuals infected with human immunodeficiency virus-type 1 (HIV-1) has important implications for therapeutic research and clinical care. HIV-1Expand
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Formation of the Isthmus of Panama
Independent evidence from rocks, fossils, and genes converge on a cohesive narrative of isthmus formation in the Pliocene. The formation of the Isthmus of Panama stands as one of the greatest naturalExpand
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Hopping Hotspots: Global Shifts in Marine Biodiversity
Hotspots of high species diversity are a prominent feature of modern global biodiversity patterns. Fossil and molecular evidence is starting to reveal the history of these hotspots. There have beenExpand
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Quantitation of HIV-1 RNA in Plasma Predicts Outcome after Seroconversion
The course of infection with human immunodeficiency virus type 1 (HIV-1) varies considerably. Although the median interval between HIV-1 infection and the development of the acquired immunodeficiencyExpand
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Environmental change preceded Caribbean extinction by 2 million years
Paleontologists typically treat major episodes of extinction as single and distinct events in which a major environmental perturbation results in a synchronous evolutionary response. Alternatively,Expand
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Middle Paleolithic Shell Beads in Israel and Algeria
Perforated marine gastropod shells at the western Asian site of Skhul and the North African site of Oued Djebbana indicate the early use of beads by modern humans in these regions. The remoteness ofExpand
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The ecology of extinction: molluscan feeding and faunal turnover in the Caribbean Neogene
Molluscan faunal turnover in the Plio–Pleistocene of the tropical western Atlantic has been attributed to drops in temperature or primary productivity, but these competing hypotheses have not beenExpand
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Eocene greenhouse climate revealed by coupled clumped isotope-Mg/Ca thermometry
Significance Reconstructing the degree of warming during geological periods of elevated CO2 provides a way of testing our understanding of the Earth system and the accuracy of climate models. WeExpand
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Amassing diversity in an ancient lake: evolution of a morphologically diverse parthenogenetic gastropod assemblage in Lake Malawi
Exceptional ecological niche diversity, clear waters and unique divergent selection pressures have often been invoked to explain high morphological and genetic diversity of taxa within ancient lakes.Expand
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Palaeogene and Neogene cold seep communities in Barbados, Trinidad and Venezuela: An overview
Palaeogene and Neogene fossiliferous carbonates from Barbados, Trinidad and northern Venezuela are interpreted to have formed at ancient cold seep sites. The hydrocarbon seepage that fuelled theseExpand
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