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Impact of forced vital capacity loss on survival after the onset of chronic lung allograft dysfunction.
TLDR
Patients with FVC decline at CLAD onset had significantly worse survival after CLAD when compared with those with preserved FVC, and a subset of patients demonstrating physiology more suggestive of restriction experience worse clinical outcomes.
Bronchiolitis obliterans syndrome: the final frontier for lung transplantation.
TLDR
A body of developing research is highlighted illustrating the mechanisms by which BOS is mediated, including alloimmune reactivity, the emerging roles of humoral and autoimmunity, activation of innate immune cells, and response to nonimmune-related allograft insults, such as infection and aspiration.
An Exome Sequencing Study to Assess the Role of Rare Genetic Variation in Pulmonary Fibrosis
TLDR
The idea that telomere dysfunction is involved in IPF pathogenesis is supported, as whole‐exome sequencing data identified TERT, RTEL1, and PARN—three telomeres‐related genes previously implicated in familial pulmonary fibrosis—as significant contributors to sporadic IPF.
Quantitative proteomics of bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis.
TLDR
The first gel-free quantitative analysis of BALF in idiopathic pulmonary fibrosis (IPF), a chronic and fatal scarring lung disease, is described, showing the utility of BALf proteomics for the molecular profiling of fibrotic lung diseases and the targeted quantitation of soluble markers of IPF.
Early and Long-term Outcomes of Older Adults after Acute Care Encounters for Chronic Obstructive Pulmonary Disease Exacerbation.
TLDR
The results suggest that addressing important comorbid conditions, such as heart failure or malnutrition, and targeting resources to oxygen-dependent or dual Medicare- and Medicaid-eligible patients may help modify these outcomes.
Thrombolytic therapy for acute pulmonary embolism: a critical appraisal.
TLDR
Historical aspects of and current evidence for thrombolytic therapy in acute PE are reviewed with specific attention to bleeding risk, and data regarding hemodynamic parameters and mortality are reviewed.
Bronchoalveolar Lavage as a Tool to Predict, Diagnose and Understand Bronchiolitis Obliterans Syndrome
TLDR
Objective criteria to qualitatively rank the strength of associations between BAL parameters and BOS are developed and applied in order to provide a comprehensive and systematic assessment of the literature.
Impact of CLAD Phenotype on Survival After Lung Retransplantation: A Multicenter Study
TLDR
Survival after re‐LTx for rCLAD is worse compared to BOS, and re‐ LTx for RCLAD should be critically discussed, particularly when additional peri‐operative risk factors are present.
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