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Glucose clamp technique: a method for quantifying insulin secretion and resistance.
Methods for the quantification of beta-cell sensitivity to glucose (hyperglycemic clamp technique) and of tissue sensitivity to insulin (euglycemic insulin clamp technique) are described.
Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging.
TLDR
Observations of health factor independent, age-related longitudinal decreases in T and free T, resulting in a high frequency of hypogonadal values, suggest that further investigation of T replacement in aged men, perhaps targeted to those with the lowest serum T concentrations, are justified.
Muscle quality. I. Age-associated differences between arm and leg muscle groups.
TLDR
Regression analysis showed that MQ, defined as PT per unit of MM, was significantly higher in the arm than in the leg across age in both genders, and the magnitude of this effect depends on the muscle group studied and the type of muscle action used to assess strength.
Age and gender comparisons of muscle strength in 654 women and men aged 20-93 yr.
TLDR
Both men and women experience age-related losses in isometric, Con, and Ecc knee extensors peak torque; however, age accounted for less of the variance in Ecc peak torque in women, and women tend to better preserve muscle quality with age for Eccpeak torque.
Longitudinal Studies on the Rate of Decline in Renal Function with Age
TLDR
Serial creatinine clearances were obtained for 446 normal volunteers in the Baltimore Longitudinal Study of Aging followed between 1958 and 1981 and there was a small group of patients who showed a statistically significant increase (P < 0.05) in Creatinine clearance with age.
Normal Human Aging: The Baltimore Longitudinal Study on Aging
Normal Human Aging is an overview of the first 23 years of research findings about the natural course of human aging. The Baltimore Longitudinal Study of Aging was started in 1958 to "trace the
Age-associated loss of power and strength in the upper extremities in women and men.
TLDR
Cross-sectional and longitudinal age-associated reductions in power and isometric strength are described for the upper extremities and the differences between power and strength changes with age in men argue for the importance of factors other than strength affecting power.
Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial.
TLDR
GH with or without sex steroids in healthy, aged women and men increased LBM and decreased fat mass and sex steroid + GH increased muscle strength marginally and VO( 2)max.
The role of muscle loss in the age-related decline of grip strength: cross-sectional and longitudinal perspectives.
TLDR
Results concur that grip strength increases into the thirties and declines at an accelerating rate after age 40, but there remain other yet undetermined factors beyond declining muscle mass to explain some of the loss of strength seen with aging.
A model of the kinetics of insulin in man.
TLDR
The design of the present study of the kinetics of insulin in man combines experimental features which obviate two of the major problems in previous insulin studies and concludes that compartment 3 insulin (rather than plasma insulin) is a more direct determinant of glucose utilization.
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