• Publications
  • Influence
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
Methods for the quantification of beta-cell sensitivity to glucose (hyperglycemic clamp technique) and of tissue sensitivity to insulin (euglycemic insulin clamp technique) are described.Expand
  • 6,853
  • 206
  • PDF
Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging.
Many studies have shown cross-sectional (and two small studies, longitudinal) declines in total and/or free testosterone (T) levels, with age, in men. The extent to which decline in T is the resultExpand
  • 2,187
  • 67
  • PDF
Muscle quality. I. Age-associated differences between arm and leg muscle groups.
To determine the differences between arm and leg muscle quality (MQ) across the adult life span in men and women, concentric (Con) and eccentric (Ecc) peak torque (PT) were measured in 703 subjectsExpand
  • 548
  • 34
  • PDF
Longitudinal Studies on the Rate of Decline in Renal Function with Age
Serial creatinine clearances (5 to 14 studies) were obtained for 446 normal volunteers in the Baltimore Longitudinal Study of Aging followed between 1958 and 1981. When those subjects with possibleExpand
  • 1,359
  • 32
The role of muscle loss in the age-related decline of grip strength: cross-sectional and longitudinal perspectives.
The decline of strength with age has often been attributed to declining muscle mass in older subjects. To investigate factors which might influence changes in strength across the life span, gripExpand
  • 564
  • 13
A model of the kinetics of insulin in man.
The design of the present study of the kinetics of insulin in man combines experimental features which obviate two of the major problems in previous insulin studies. (a) The use of radioiodinatedExpand
  • 493
  • 11
  • PDF
Impact of age on weight goals.
Although the health hazards due to excessive obesity and excessive leanness are multiple and diverse, weight recommendations for over 40 years have been based solely on the risk of dying. The weightExpand
  • 289
  • 10
The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study.
Standard true 24-hour creatinine clearance determinations were performed on 884 subjects of the Baltimore Longitudinal Study. On the basis of clinical data, subjects were placed in categoriesExpand
  • 1,025
  • 9
Oral glucose augmentation of insulin secretion. Interactions of gastric inhibitory polypeptide with ambient glucose and insulin levels.
Gastric inhibitory polypeptide, or GIP, has been postulated as the major enteric hormonal mediator of insulin release. The release of immuno-reactive GIP (IR-GIP) after oral glucose and its role inExpand
  • 248
  • 9
  • PDF
Muscle quality and age: cross-sectional and longitudinal comparisons.
We addressed whether muscle quality (force per unit muscle mass) changes with age in cross-sectional and longitudinal analyses from three groups from the Baltimore Longitudinal Study of Aging: (1)Expand
  • 206
  • 9