• Publications
  • Influence
Dexmedetomidine: Applications in pediatric critical care and pediatric anesthesiology
  • J. Tobias
  • Medicine
    Pediatric critical care medicine : a journal of…
  • 1 March 2007
TLDR
Given its favorable sedative and anxiolytic properties combined with its limited effects on hemodynamic and respiratory function, there is growing interest in and reports of its use in the pediatric population in various clinical scenarios.
Sedation During Mechanical Ventilation in Infants and Children: Dexmedetomidine Versus Midazolam
TLDR
At a dose of 0.25 μg/kg/h, dexmedetomidine provided more effective sedation as demonstrated by the need for fewer bolus doses of morphine, a decrease in the 24-hour requirements for supplemental morphine, as well as a decreases in the total number of assessment points with a Ramsay score of 1 (inadequate sedation) and the number of patients who had a Ramsay scores of 1.
Intraosseous Infusions: A Review for the Anesthesiologist with a Focus on Pediatric Use
TLDR
Anyone providing anesthesia care for infants and children may want to become facile with the use of IO infusions for selected indications with limited emphasis on its potential use in the perioperative setting.
Dexmedetomidine to treat opioid withdrawal in infants following prolonged sedation in the pediatric ICU.
  • J. Tobias
  • Medicine
    Journal of opioid management
  • 1 July 2006
TLDR
It is concluded that dexmedetomidine offers a viable option for such issues in the pediatric intensive care unit (PICU) setting and effectively controlled the signs and symptoms of withdrawal in the seven patients.
The Correlation of the Bispectral Index Monitor with Clinical Sedation Scores During Mechanical Ventilation in the Pediatric Intensive Care Unit
TLDR
The BIS monitor may be a useful adjunct for the assessment of sedation in PICU patients and was independent of the drug(s) used for sedation.
Strategies for minimizing blood loss in orthopedic surgery.
TLDR
The goal of performing major orthopedic surgical procedures without the use of allogeneic blood products can only be accomplished by combining several of these techniques.
Prospective study of airway management of children requiring endotracheal intubation before admission to a pediatric intensive care unit
TLDR
Most variances associated with airway management in children can be avoided by improved education regarding appropriate ET tube size, appropriate medication use, and improved training for evaluation of ET tube placement.
Dexmedetomidine in the Treatment of Withdrawal Syndromes in Cardiothoracic Surgery Patients
TLDR
The authors present their experience with the use of dexmedetomidine to control withdrawal behavior in 3 patients following cardiothoracic surgery, and it appears that dexmedetsamine may be a useful agent for treatment of substance withdrawal in the intensive care setting.
Subcutaneous administration of fentanyl and midazolam to prevent withdrawal after prolonged sedation in children.
  • J. Tobias
  • Medicine
    Critical care medicine
  • 1 October 1999
TLDR
The subcutaneous route provides an effective alternative to intravenous administration that allows for gradual weaning from sedative/analgesic agents after prolonged sedation while eliminating the need to maintain intravenous access.
Cerebral oxygenation monitoring: near-infrared spectroscopy
  • J. Tobias
  • Medicine
    Expert review of medical devices
  • 1 March 2006
TLDR
The following article reviews the latest technology available to monitor cerebral oxygenation, near-infrared spectroscopy, its advantages and disadvantages, the currently available evidence-based medicine that demonstrates that this technology can identify deficits in cerebral oxygenations, and that monitoring such deficits allows for therapy to reverse cerebral oxygenated issues and thereby prevent long-term neurological sequelae.
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