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Mapping behaviorally relevant neural circuits with immediate-early gene expression
Immediate-early genes have gained widespread popularity as activity markers for mapping neuronal circuits involved in specific behaviors in many different species. In situ immediate early geneExpand
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In vivo hyperspectral confocal fluorescence imaging to determine pigment localization and distribution in cyanobacterial cells
Hyperspectral confocal fluorescence imaging provides the opportunity to obtain individual fluorescence emission spectra in small (≈0.03-μm3) volumes. Using multivariate curve resolution, individualExpand
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Delivering CRISPR: a review of the challenges and approaches
Abstract Gene therapy has long held promise to correct a variety of human diseases and defects. Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the mechanism ofExpand
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Carotenoid Distribution in Living Cells of Haematococcus pluvialis (Chlorophyceae)
Haematococcus pluvialis is a freshwater unicellular green microalga belonging to the class Chlorophyceae and is of commercial interest for its ability to accumulate massive amounts of the redExpand
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Hyperspectral confocal microscope.
We have developed a new, high performance, hyperspectral microscope for biological and other applications. For each voxel within a three-dimensional specimen, the microscope simultaneously recordsExpand
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Design, construction, characterization, and application of a hyperspectral microarray scanner.
We describe the design, construction, and operation of a hyperspectral microarray scanner for functional genomic research. The hyperspectral instrument operates with spatial resolutions ranging fromExpand
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Basic Culturing and Analytical Measurement Techniques
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Raman spectroscopic imaging markers for fatigue-related microdamage in bovine bone.
Raman spectroscopic markers have been determined for fatigue-related microdamage in bovine bone. Microdamage was induced using a cyclic fatigue loading regime. After loading, the specimens wereExpand
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Photosynthetic Pigment Localization and Thylakoid Membrane Morphology Are Altered in Synechocystis 6803 Phycobilisome Mutants1[C][W]
Cyanobacteria are oxygenic photosynthetic prokaryotes that are the progenitors of the chloroplasts of algae and plants. These organisms harvest light using large membrane-extrinsic phycobilisomeExpand
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Characterization of differential Toll-like receptor responses below the optical diffraction limit.
Many membrane receptors are recruited to specific cell surface domains to form nanoscale clusters upon ligand activation. This step appears to be necessary to initiate cell signaling, includingExpand
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