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Delivering CRISPR: a review of the challenges and approaches
TLDR
The focus then turns to the most difficult barrier to potential in vivo use of CRISPR/Cas9, delivery, and detail the various cargos and delivery vehicles reported for CRISpr/ Cas9, including physical delivery vehicles, viral delivery methods, and non-viral delivery methods.
In vivo hyperspectral confocal fluorescence imaging to determine pigment localization and distribution in cyanobacterial cells
TLDR
Localize, in vivo, photosynthesis-related pigments (chlorophylls, phycobilins, and carotenoids) in wild-type and mutant cells of the cyanobacterium Synechocystis sp.
Carotenoid Distribution in Living Cells of Haematococcus pluvialis (Chlorophyceae)
Haematococcus pluvialis is a freshwater unicellular green microalga belonging to the class Chlorophyceae and is of commercial interest for its ability to accumulate massive amounts of the red
Design, construction, characterization, and application of a hyperspectral microarray scanner.
TLDR
The design, construction, and operation of a hyperspectral microarray scanner for functional genomic research and separation of fluorescent label emission from the spectrally overlapping emission due to the underlying glass substrate are described.
Hyperspectral confocal microscope.
TLDR
A new, high performance, hyperspectral microscope for biological and other applications that eliminates curvature and keystone artifacts that often plague spectral imaging systems is developed.
Raman spectroscopic imaging markers for fatigue-related microdamage in bovine bone.
TLDR
Raman imaging confirms the qualitative relationship between the Raman spectral signature of bone mineral and the type of microdamage in bovine bone and two tentative explanations for the presence of less carbonated phosphate in damaged regions are proposed.
Gene editing and CRISPR in the clinic: current and future perspectives
TLDR
The current status and scientific basis of clinical trials featuring ZFNs, TALENs, andCRISPR-based genome editing, the known limitations of CRISPR use in humans, and the rapidly developing CRISpr engineering space that should lay the groundwork for further translation to clinical application are examined.
Formation of a Mast Cell Synapse: FcεRI Membrane Dynamics upon Binding Mobile or Immobilized Ligands on Surfaces
TLDR
The data indicate that FcεRI cross-linking is not an obligatory step in triggering mast cell signaling and suggest that dense populations of mobile receptors are capable of initiating low-level degranulation upon ligand recognition.
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