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Delivering CRISPR: a review of the challenges and approaches
The focus then turns to the most difficult barrier to potential in vivo use of CRISPR/Cas9, delivery, and detail the various cargos and delivery vehicles reported for CRISpr/ Cas9, including physical delivery vehicles, viral delivery methods, and non-viral delivery methods.
Mapping behaviorally relevant neural circuits with immediate-early gene expression
In vivo hyperspectral confocal fluorescence imaging to determine pigment localization and distribution in cyanobacterial cells
- W. Vermaas, J. Timlin, D. Haaland
- Biology, ChemistryProceedings of the National Academy of Sciences
- 11 March 2008
Localize, in vivo, photosynthesis-related pigments (chlorophylls, phycobilins, and carotenoids) in wild-type and mutant cells of the cyanobacterium Synechocystis sp.
Carotenoid Distribution in Living Cells of Haematococcus pluvialis (Chlorophyceae)
- A. Collins, Howland D. T. Jones, Danxiang Han, Q. Hu, T. Beechem, J. Timlin
- BiologyPloS one
- 6 September 2011
Haematococcus pluvialis is a freshwater unicellular green microalga belonging to the class Chlorophyceae and is of commercial interest for its ability to accumulate massive amounts of the red…
Design, construction, characterization, and application of a hyperspectral microarray scanner.
- M. Sinclair, J. Timlin, D. Haaland, M. Werner-Washburne
- Biology, Environmental ScienceApplied optics
- 1 April 2004
The design, construction, and operation of a hyperspectral microarray scanner for functional genomic research and separation of fluorescent label emission from the spectrally overlapping emission due to the underlying glass substrate are described.
Basic Culturing and Analytical Measurement Techniques
Hyperspectral confocal microscope.
A new, high performance, hyperspectral microscope for biological and other applications that eliminates curvature and keystone artifacts that often plague spectral imaging systems is developed.
Raman spectroscopic imaging markers for fatigue-related microdamage in bovine bone.
Raman imaging confirms the qualitative relationship between the Raman spectral signature of bone mineral and the type of microdamage in bovine bone and two tentative explanations for the presence of less carbonated phosphate in damaged regions are proposed.
Gene editing and CRISPR in the clinic: current and future perspectives
- M. Hirakawa, Raga Krishnakumar, J. Timlin, J. Carney, K. Butler
- BiologyBioscience reports
- 24 March 2020
The current status and scientific basis of clinical trials featuring ZFNs, TALENs, andCRISPR-based genome editing, the known limitations of CRISPR use in humans, and the rapidly developing CRISpr engineering space that should lay the groundwork for further translation to clinical application are examined.
Formation of a Mast Cell Synapse: FcεRI Membrane Dynamics upon Binding Mobile or Immobilized Ligands on Surfaces
- A. Carroll-Portillo, K. Spendier, J. Timlin
- Biology, ChemistryThe Journal of Immunology
- 30 December 2009
The data indicate that FcεRI cross-linking is not an obligatory step in triggering mast cell signaling and suggest that dense populations of mobile receptors are capable of initiating low-level degranulation upon ligand recognition.