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Principles of biochemical toxicology
- J. Timbrell
- 30 October 1991
Dose-response relationship factors affecting toxic response - disposition, metabolism factors affecting metabolism and disposition toxic responses to foreign compounds biochemical mechanisms of… Expand
In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride.
Different sensitivity was observed for each assay with the neutral red and the MTT assay being the most sensitive in detecting cytotoxic events compared to the LDH leakage and the protein assay. Expand
Biotransformation of Xenobiotics
Xenobiotics, which are absorbed into biological systems by passive diffusion across membranes are usually lipid soluble and not ideally suited for excretion. Indeed very lipophilic substances may… Expand
Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis.
The clinical spectrum of isoniazid-induced liver injury seems to be clinically, biochemically, and histologically indistinguishable from viral hepatitis, except that the injury occurs primarily in… Expand
Biomarkers in toxicology.
- J. Timbrell
- Biology, Medicine
- 7 August 1998
The use of biomarkers in toxicology is becoming increasingly important and some of the new developments, particularly in relation to biomarkers of exposure and response, are mentioned. Expand
Introduction to Toxicology
- J. Timbrell
- Environmental Science
- 26 February 1989
Disposition of Toxic Compunds Types of Exposure and Response Drugs as Toxic Substances Industrial Chemicals Food Additives and Contaminants Pesticides Environmental Pollutants Natural Products… Expand
Increased incidence of isoniazid hepatitis in rapid acetylators: possible relation to hydrazine metabolites
- Jerry R. Mitchell, U. Thorgeirsson, +5 authors H. Keiser
- Clinical pharmacology and therapeutics
- 1 July 1975
It is suggested that release of the hepatotoxic hydrazino moiety of isoniazid in man is responsible for isoniaZid liver injury. Expand
Isoniazid and iproniazid: activation of metabolites to toxic intermediates in man and rat.
- S. Nelson, J. Mitchell, J. Timbrell, W. Snodgrass, G. Corcoran
- Chemistry, Medicine
- 3 September 1976
Covalent binding of these metabolites to liver macromolecules paralleled hepatic cellular necrosis and the metabolites formed from these and probably other monosubstituted hydrazines are reactive electrophiles. Expand
The in vivo and in vitro protective properties of taurine.
Taurine protects isolated hepatocytes against carbon tetrachloride, hydrazine and 1,4-naphthoquinone but not against allyl alcohol, alpha- naphthylisothiocyanate (ANIT) or diaminodiphenyl methane (DAPM) cytotoxicity. Expand