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A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.
Counts of macroscopic splenic colonies were used to obtain an estimate of the radiation sensitivity of normal mouse bone marrow progenitor cells. Reproduced from Radiation Research 1961(Feb); 14(2):Expand
Ethical issues in qualitative research on internet communities
TLDR
Internet communities (such as mailing lists, chat rooms, newsgroups, or discussion boards on websites) are rich sources of qualitative data for health researchers and Qualitative analysis of internet postings may help to systematise needs, values, and preferences of consumers and professionals relevant to health and health care. Expand
Cytological Demonstration of the Clonal Nature of Spleen Colonies Derived from Transplanted Mouse Marrow Cells
TLDR
Unique radiation-induced marker chromosomes were used to obtain direct cytological evidence that the spleen colonies are clones, demonstrating the advantages inherent in the clonal approach to studies of the genetic and physiological properties of cells. Expand
A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS.
TLDR
An analysis of variation in the distribution of CFU in macroscopic colonies indicates that it might be generated by a well-known probabilistic ("stochastic") process, the "birth-and-death" process. Expand
THE DISTRIBUTION OF COLONY-FORMING CELLS AMONG SPLEEN COLONIES.
Progenitor cells that are recognized by their ability to form colonies of descendants in the spleens of irradiated mice have the capacity for self-renewal. The distribution of new colony-formingExpand
The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation into irradiated mice.
TLDR
Quantitative bone marrow transplantation was used to obtain an estimate of the radiation sensitivity of normal mouse bone marrow progenitor cells, and this estimate was lower than expected because fewer cells were transplanted. Expand
Characterization of the factor in L‐cell conditioned medium capable of stimulating colony formation by mouse marrow cells in culture
TLDR
Medium harvested from cultures of mouse L‐cells contains “conditioning factor activity” (CFA) that may be detected by its ability to stimulate colony formation by mouse marrow cells in culture, and characterization of trypsin‐digested material indicated that only part of the molecule is essential for biological activity. Expand
A cytological study of the capacity for differentiation of normal hemopoietic colony‐forming cells
TLDR
Support is provided for the view that colony forming hemopoietic stem cells are multipotent, and that differentiation along more than one pathway can occur during the formation of macroscopic splenic colonies. Expand
Cancer Patients: Their Desire for Information and Participation in Treatment Decisions
TLDR
The results of this study indicate that patients may actively seek information to satisfy an as yet unidentified aspect of psychological autonomy that does not necessarily include participation in decision making. Expand
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