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A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.
Counts of macroscopic splenic colonies were used to obtain an estimate of the radiation sensitivity of normal mouse bone marrow progenitor cells. Reproduced from Radiation Research 1961(Feb); 14(2):… Expand
Ethical issues in qualitative research on internet communities
Internet communities (such as mailing lists, chat rooms, newsgroups, or discussion boards on websites) are rich sources of qualitative data for health researchers and Qualitative analysis of internet postings may help to systematise needs, values, and preferences of consumers and professionals relevant to health and health care. Expand
Cytological Demonstration of the Clonal Nature of Spleen Colonies Derived from Transplanted Mouse Marrow Cells
Unique radiation-induced marker chromosomes were used to obtain direct cytological evidence that the spleen colonies are clones, demonstrating the advantages inherent in the clonal approach to studies of the genetic and physiological properties of cells. Expand
A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS.
- J. Till, E. McCulloch, L. Siminovitch
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
An analysis of variation in the distribution of CFU in macroscopic colonies indicates that it might be generated by a well-known probabilistic ("stochastic") process, the "birth-and-death" process. Expand
THE DISTRIBUTION OF COLONY-FORMING CELLS AMONG SPLEEN COLONIES.
- L. Siminovitch, E. McCulloch, J. Till
- Biology, Medicine
- Journal of cellular and comparative physiology
- 1 December 1963
Progenitor cells that are recognized by their ability to form colonies of descendants in the spleens of irradiated mice have the capacity for self-renewal. The distribution of new colony-forming… Expand
The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation into irradiated mice.
Quantitative bone marrow transplantation was used to obtain an estimate of the radiation sensitivity of normal mouse bone marrow progenitor cells, and this estimate was lower than expected because fewer cells were transplanted. Expand
Characterization of the factor in L‐cell conditioned medium capable of stimulating colony formation by mouse marrow cells in culture
Medium harvested from cultures of mouse L‐cells contains “conditioning factor activity” (CFA) that may be detected by its ability to stimulate colony formation by mouse marrow cells in culture, and characterization of trypsin‐digested material indicated that only part of the molecule is essential for biological activity. Expand
COLONY ASSAY FOR PROLIFERATIVE BLAST CELLS CIRCULATING IN MYELOBLASTIC LEUKÆMIA
A cytological study of the capacity for differentiation of normal hemopoietic colony‐forming cells
- A. Wu, J. Till, L. Siminovitch, E. McCulloch
- Biology, Medicine
- Journal of cellular physiology
- 1 April 1967
Support is provided for the view that colony forming hemopoietic stem cells are multipotent, and that differentiation along more than one pathway can occur during the formation of macroscopic splenic colonies. Expand
Cancer Patients: Their Desire for Information and Participation in Treatment Decisions
- H. Sutherland, H. Llewellyn-Thomas, G. Lockwood, D. Tritchler, J. Till
- Psychology, Medicine
- Journal of the Royal Society of Medicine
- 1 May 1989
The results of this study indicate that patients may actively seek information to satisfy an as yet unidentified aspect of psychological autonomy that does not necessarily include participation in decision making. Expand