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An Oestrogen Receptor α-bound Human Chromatin Interactome
Genomes are organized into high-level three-dimensional structures, and DNA elements separated by long genomic distances can in principle interact functionally. Many transcription factors bind toExpand
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Whole-Genome Cartography of Estrogen Receptor α Binding Sites
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor α (ERα) binding sites in MCF-7 breast cancer cells. We identified 1,234 highExpand
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Integrative model of genomic factors for determining binding site selection by estrogen receptor-α
A major question in transcription factor (TF) biology is why a TF binds to only a small fraction of motif eligible binding sites in the genome. Using the estrogen receptor‐α as a model system, weExpand
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Discovery of estrogen receptor α target genes and response elements in breast tumor cells
BackgroundEstrogens and their receptors are important in human development, physiology and disease. In this study, we utilized an integrated genome-wide molecular and computational approach toExpand
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DAX-1 Functions as an LXXLL-containing Corepressor for Activated Estrogen Receptors*
We have discovered that the orphan receptor DAX-1 (NROB1) interacts with the estrogen receptors ERα and ERβ. Interaction occurs with ligand-activated ERs in solution and on DNA and is mediated by theExpand
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De-Novo Identification of PPARγ/RXR Binding Sites and Direct Targets during Adipogenesis
Background The pathophysiology of obesity and type 2 diabetes mellitus is associated with abnormalities in endocrine signaling in adipose tissue and one of the key signaling affectors operative inExpand
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The Orphan Nuclear Receptor SHP Inhibits Agonist-dependent Transcriptional Activity of Estrogen Receptors ERα and ERβ*
SHP (short heterodimer partner) is an unusual orphan nuclear receptor that contains a putative ligand-binding domain but lacks a conserved DNA-binding domain. Although no conventional receptorExpand
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The Orphan Nuclear Receptor SHP Utilizes Conserved LXXLL-Related Motifs for Interactions with Ligand-Activated Estrogen Receptors
ABSTRACT SHP (short heterodimer partner) is an unusual orphan nuclear receptor consisting only of a ligand-binding domain, and it exhibits unique features of interaction with conventional nuclearExpand
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Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities.
The covalent structures of two, novel, neutrophile, leucocyte-derived, strongly basic proteins of porcine and human origin have been determined by microsequencing in combination with time-of-flightExpand
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HES-1, a novel target gene for the aryl hydrocarbon receptor.
Known mainly for its role as a toxin sensor, the aryl hydrocarbon receptor (AhR) complex is also involved in homeostasis regulation and differentiation processes and activated by xenobiotic compoundsExpand
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