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A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins.
TLDR
Naturally occurring isoflavones isolated with soy protein reduce the plasma concentrations of total and LDL cholesterol without affecting concentrations of triglycerides or high-density lipoprotein cholesterol in mildly hypercholesterolemic volunteers consuming a National Cholesterol Education Program Step I diet. Expand
Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors
TLDR
Results from a meta-analysis and post-trial follow-up from a single published study suggest that IMT meets established statistical criteria by accounting for intervention effects in regression models, but do not establish that it may serve universally as a surrogate marker in trials of other agents. Expand
Association between duration of overall and abdominal obesity beginning in young adulthood and coronary artery calcification in middle age.
TLDR
The duration of overall and abdominal obesity was associated with subclinical coronary heart disease and its progression through midlife independent of the degree of adiposity, and preventing or at least delaying the onset of obesity in young adulthood may lower the risk of developing atherosclerosis through middle age. Expand
Sex-specific associations of magnetic resonance imaging-derived intra-abdominal and subcutaneous fat areas with conventional anthropometric indices. The Atherosclerosis Risk in Communities Study.
TLDR
The authors conclude that when waist circumference or body mass index is used as a surrogate for intra-abdominal fat area in men, a quadratic term should be included in the analysis as a predictor variable. Expand
Effect of chromium picolinate on insulin sensitivity in vivo
TLDR
Investigation of the effect of chromium (Cr) supplementation on insulin sensitivity and body composition in obese subjects with a family history of Type 2 diabetes suggests that Cr may alter insulin sensitivity independent of a change in weight or body fat percentage. Expand
Association of Fitness in Young Adulthood With Survival and Cardiovascular Risk: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.
TLDR
Higher levels of fitness at baseline and improvement in fitness early in adulthood are favorably associated with lower risks for CVD and mortality and regular efforts to ascertain and improve CRF in young adulthood may play a critical role in promoting cardiovascular health and interrupting early CVD pathogenesis. Expand
Associations between nonalcoholic fatty liver disease and subclinical atherosclerosis in middle-aged adults: the Coronary Artery Risk Development in Young Adults Study.
TLDR
It is suggested that obesity attenuates the relationship between NAFLD and subclinical atherosclerosis, and further studies evaluating the role ofNAFLD duration on atherosclerotic progression and cardiovascular events are needed. Expand
Associations of risk factors with segment-specific intimal-medial thickness of the extracranial carotid artery.
TLDR
Assessment of associations of risk factors with intimal-medial thickness in 280 individuals older than 45 years found sex, postmenopausal status, LDL cholesterol, systolic blood pressure, and history of myocardial infarction all had statistically significant relationships that were fairly homogeneous among arterial sites. Expand
Effect of simvastatin (80 mg) on coronary and abdominal aortic arterial calcium (from the coronary artery calcification treatment with zocor [CATZ] study).
TLDR
In conclusion, simvastatin treatment does not reduce progression of CAC or AAC compared with placebo, whereas lipids remained unchanged for subjects randomized to receive placebo. Expand
Associations of Extracranial Carotid Atherosclerosis Progression With Coronary Status and Risk Factors in Patients With and Without Coronary Artery Disease
TLDR
Male sex, increased waist to hip ratio, cigarette smoking, increased triglycerides, and decreased HDL cholesterol were associated with increased progression in CAD patients, and risk factors were related to progression in them. Expand
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