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Free radicals and antioxidants in normal physiological functions and human disease.
Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing. Expand
Role of oxygen radicals in DNA damage and cancer incidence
The epidemiological trials together with in vitro experiments suggest that the optimal approach is to reduce endogenous and exogenous sources of oxidative stress, rather than increase intake of anti-oxidants. Expand
AirSR, a [2Fe-2S] cluster-containing two-component system, mediates global oxygen sensing and redox signaling in Staphylococcus aureus.
A Staphylococcus aureus two-component system, AirSR (anaerobic iron-sulfur cluster-containing redox sensor regulator), responds to oxidation signals by using a redox-active [2Fe-2S] cluster in the sensor kinase AirS to regulate gene regulation under O(2)-limited conditions. Expand
The metal centers of particulate methane monooxygenase from Methylosinus trichosporium OB3b.
PMMO from a second organism, Methylosinus trichosporium OB3b, has been purified and characterized by spectroscopic and crystallographic methods and indicates that type 2 Cu(II) is present as two distinct species. Expand
High-Affinity Binding Site for Copper(II) in Human and Dog Serum Albumins (an EPR Study)
Spectroscopic studies have been performed to investigate the high-affinity binding site for copper in human serum albumin (HSA) and dog serum albumin (DSA). A new approach based on exposure toExpand
Role of the [Fe4S4] cluster in mediating disulfide reduction in spinach ferredoxin:thioredoxin reductase.
Thioredoxin reduction in plant chloroplasts is catalyzed by a unique class of disulfide reductases which use a one-electron donor, [Fe2S2]2+,+ ferredoxin, and has an active site involving a disulfideExpand
The copper chelator methanobactin from Methylosinus trichosporium OB3b binds copper(I).
The oxidation state of copper bound to methanobactin, a small siderophore-like molecule from the methanotroph Methylosinus trichosporium OB3b, was investigated and it is established definitively that it binds Cu(I) and suggested that methanOBactin itself reduces Cu(II) to Cu( I). Expand
Characterization of the particulate methane monooxygenase metal centers in multiple redox states by X-ray absorption spectroscopy.
Extended X-ray absorption fine structure (EXAFS) analysis reveals a Cu-Cu interaction in all redox forms of the enzyme, and analysis of Fe EXAFS data combined with electron paramagnetic resonance (EPR) spectra indicates that Fe, present as Fe(III), is consistent with heme impurities. Expand
Electronic structure of four-coordinate C3v nickel(II) scorpionate complexes: investigation by high-frequency and -field electron paramagnetic resonance and electronic absorption spectroscopies.
A description of electronic structure and bonding in a pseudotetrahedral nickel(II) complex can enhance the understanding of similar sites in metalloproteins, both native nickel enzymes and nickel-substituted zinc enzymes. Expand
A Multinuclear ENDOR Study of the C-Cluster in CO Dehydrogenase from Clostridium thermoaceticum: Evidence for HxO and Histidine Coordination to the [Fe4S4] Center
The C-cluster of carbon monoxide dehydrogenase (CODH) catalyzes the reversible oxidation of CO to form CO2. This study reports electron nuclear double resonance (ENDOR) spectroscopy of theExpand