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Homeostatic neurogenesis in the adult hippocampus does not involve amplification of Ascl1(high) intermediate progenitors.
- S. Lugert, M. Vogt, J. Tchorz, M. Mueller, C. Giachino, V. Taylor
- Biology, Medicine
- Nature communications
- 14 February 2012
Neural stem/progenitor cells generate neurons in the adult hippocampus. Neural stem cells produce transient intermediate progenitors (type-2 cells), which generate neuroblasts (type-3 cells) that… Expand
R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5
The Wnt/β-catenin signaling pathbway controls many important biological processes. R-Spondin (RSPO) proteins are a family of secreted molecules that strongly potentiate Wnt/β-catenin signaling,… Expand
Constitutive Notch2 signaling induces hepatic tumors in mice
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCC) are the most common liver tumors and a leading cause for cancer‐related death in men. Notch2 regulates cellular differentiation in the… Expand
The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size
LGR4/5 receptors and their cognate RSPO ligands potentiate Wnt/β-catenin signalling and promote proliferation and tissue homeostasis in epithelial stem cell compartments. In the liver, metabolic… Expand
Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart.
- Ji-wen Yang, S. Bücker, +9 authors T. Braun
- Chemistry, Medicine
- Cardiovascular research
- 1 November 2012
AIMS The ventricular wall of the heart is composed of trabeculated and compact layers, which are separated by yet unknown processes during embryonic development. Here, we wanted to explore the role… Expand
A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes.
In the brain, Notch signaling maintains normal neural stem cells, but also brain cancer stem cells, indicating an oncogenic role. Here, we identify an unexpected tumor suppressor function for Notch… Expand
Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice
- J. Tchorz, J. Kinter, M. Mueller, L. Tornillo, M. Heim, B. Bettler
- Biology, Medicine
- 1 September 2009
Intrahepatic bile duct (IHBD) development begins with the differentiation of hepatoblasts into a single continuous biliary epithelial cell (BEC) layer, called the ductal plate. During ductal plate… Expand
Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice.
Lgr4 and Lgr5 are known markers of adult and embryonic tissue stem cells in various organs. However, whether Lgr4 and Lgr5 are important for embryonic development remains unclear. To study their… Expand
A Modified RMCE-Compatible Rosa26 Locus for the Expression of Transgenes from Exogenous Promoters
Generation of gain-of-function transgenic mice by targeting the Rosa26 locus has been established as an alternative to classical transgenic mice produced by pronuclear microinjection. However,… Expand
YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors
The Yes‐associated protein (YAP)/Hippo pathway has been implicated in tissue development, regeneration, and tumorigenesis. However, its role in cholangiocarcinoma (CC) is not established. We show… Expand