• Publications
  • Influence
Plant part substitution--a way to conserve endangered medicinal plants?
The concept of plant substitution is outlined, using preliminary results of recent investigations into four of the most important and most threatened South African medicinal plants - Eucomis autumnalis (bulb), Siphonochilus aethiopicus (rhizome), Ocotea bullata (bark), and Warburgia salutaris (barks) - as a demonstration of the kind of research necessary. Expand
The effects of interferon-alpha on the production and action of other cytokines.
Various interferon-alpha preparations, either as individual subtypes or natural mixtures, induce or inhibit expression of several other cytokines, as well as cytokine receptors and chemokines, which may amplify the effects of IFN-alpha treatment. Expand
Lung-specific induction of heme oxygenase-1 and hyperoxic lung injury.
It is demonstrated that IT Hb induces lung HO-1 in the rat and protects against hyperoxia; however, the protection is not mediated by increased HO enzyme activity. Expand
Investigation of the antimutagenic effects of selected South African medicinal plant extracts.
The preliminary investigation shows that plant extracts used in traditional medicine may have particular effects with regard to mutagenicity and antimutagenicity indicating careful use in some instances and the need to isolate their active principles for further research. Expand
Induction of ferritin and heme oxygenase-1 by endotoxin in the lung.
Results indicate that intratracheal LPS rapidly induces ferritin protein in the lung independently of its mRNA synthesis or HO enzyme activity. Expand
Nucleus accumbens muscarinic receptors in the control of behavioral depression: antidepressant-like effects of local M1 antagonist in the Porsolt swim test
It is suggested that muscarinic receptors in the nucleus accumbens can control immobility in the Porsolt swim test. Expand
Inhibition of interferon action by actinomycin.
  • J. Taylor
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 24 January 1964
A novel bioassay for the determination of neutralizing antibodies to IFN-beta1b.
The new MxA gene-induction bioassay is adapted to measure neutralizing antibodies to interferon- beta1b (IFN-beta1b, the active ingredient in Betaseron) in sera from patients treated with Betaserson, and validated to quantify neutralizing titers of 1:20 and above. Expand
A multicentre study comparing two methods for serum free light chain analysis
Serum free light chain analysis and monoclonal antisera analysis cannot be used interchangeably, especially if monitoring patient responses to therapy. Expand
Phomalairdenone: a new host-selective phytotoxin from a virulent type of the blackleg fungus Phoma lingam.
The chemical structure and bioactivity of phomalairdenone (7), a new sesquiterpenic host-selective phytotoxin produced by an unusual virulent type isolate of the blackleg fungus [Phoma lingam,Expand