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Telomeric Expression Sites Are Highly Conserved in Trypanosoma brucei
Phylogenetic analysis of constituent ESAG families suggests that BESs are sequence mosaics and that extensive recombination has shaped the evolution of the BES repertoire, a widely used strategy for immune evasion in pathogens, and telomere biology.
Diversity Considerations in HIV-1 Vaccine Selection
Consensus or ancestor sequences could be used in vaccine design to minimize the genetic differences between vaccine strains and contemporary isolates, effectively reducing the extent of diversity by half.
Switching trypanosome coats: what's in the wardrobe?
TbISWI Regulates Multiple Polymerase I (Pol I)-Transcribed Loci and Is Present at Pol II Transcription Boundaries in Trypanosoma brucei
The results indicate that TbISWI is a versatile chromatin remodeler that regulates transcription at multiple Pol I loci and is particularly abundant at many Pol II transcription boundaries in T. brucei.
Sperm competition and the dynamics of X chromosome drive: stability and extinction.
A model of the effects of sperm competition on a driving X chromosome shows that opposing trends in male and female mating rates can result in two coexisting locally stable equilibria, one corresponding to a balanced polymorphism of the SR and ST alleles and the second to fixation of the ST allele.
Accelerated Diversification of Nonhuman Primate Malarias in Southeast Asia: Adaptive Radiation or Geographic Speciation?
It is hypothesized that the diversification of this group of parasites has been facilitated by the diversity, geographic distributions, and demographic histories of their primate hosts, and phylogenetic analysis of data suggests that the malaria parasites infecting Southeast Asian macaques and their relatives are speciating three to four times more rapidly than those with other mammalian hosts such as lemurs and African apes.
A coalescent dual process in a Moran model with genic selection, and the lambda coalescent limit.
The Common Ancestor Process for a Wright-Fisher Diffusion
- J. Taylor
- 6 January 2007
This work describes the process of substitutions to the common ancestor of each population using the structured coalescent process introduced by Kaplan et al. (1988), and shows that the theory can be formally extended to diffusion models with more than two genetic backgrounds, but that it leads to systems of singular partial differential equations which it is unable to solve.
The Evolutionary History of Plasmodium vivax as Inferred from Mitochondrial Genomes: Parasite Genetic Diversity in the Americas
It is proposed that, unlike in Asia where human migration increases local genetic diversity, the combined effects of the geographical structure and the low incidence of vivax malaria in the Americas has resulted in patterns of low local but high regional genetic diversity.