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An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response
This work has identified a previously unknown IAV protein that modulates the host response to infection, a finding with important implications for understanding IAV pathogenesis. Expand
Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus
The hemagglutinin structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA, which suggests a path for this H 5N1 virus to gain a foothold in the human population. Expand
The pathology of influenza virus infections.
The spectrum of pathologic changes described in the 1918 influenza pandemic is not significantly different from the histopathology observed in other less lethal pandemics or even in deaths occurring during seasonal influenza outbreaks. Expand
The genomic and epidemiological dynamics of human influenza A virus
It is shown that the genomic evolution of influenza A virus is characterized by a complex interplay between frequent reassortment and periodic selective sweeps, suggesting a sink–source model of viral ecology in which new lineages are seeded from a persistent influenza reservoir to sink populations in temperate regions. Expand
Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities.
The species barrier, as defined by the receptor specificity preferences of 1918 human viruses compared to likely avian virus progenitors, can be circumvented by changes at only two positions in the HA receptor binding site. Expand
Characterization of the 1918 influenza virus polymerase genes
The influenza A viral heterotrimeric polymerase complex (PA, PB1, PB2) is known to be involved in many aspects of viral replication and to interact with host factors, thereby having a role in hostExpand
Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness.
If severe pandemic influenza is largely a problem of viral-bacterial copathogenesis, pandemic planning needs to go beyond addressing the viral cause alone (e.g., influenza vaccines and antiviral drugs). Expand
Influenza virus evolution, host adaptation, and pandemic formation.
The evolution of influenza A viruses in their reservoir hosts is reviewed and genetic changes associated with introduction of novel viruses into humans, leading to pandemics and the establishment of seasonal viruses are discussed. Expand
1918 Influenza: the Mother of All Pandemics
New information about the 1918 virus is emerging, for example, sequencing of the entire genome from archival autopsy tissues, but, the viral genome alone is unlikely to provide answers to some critical questions. Expand
Whole-Genome Analysis of Human Influenza A Virus Reveals Multiple Persistent Lineages and Reassortment among Recent H3N2 Viruses
A phylogenetic analysis of 156 complete genomes of human H3N2 influenza A viruses collected between 1999 and 2004 from New York State, United States demonstrated that multiple lineages can co-circulate, persist, and reassort in epidemiologically significant ways, and underscore the importance of genomic analyses for future influenza surveillance. Expand