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Opiate self-administration as a measure of chronic nociceptive pain in arthritic rats
Preclinical in vivo antitumor activity of vinflunine, a novel fluorinated Vinca alkaloid
- A. Kruczynski, F. Colpaert, J. Tarayre, P. Mouillard, J. Fahy, B. Hill
- ChemistryCancer Chemotherapy and Pharmacology
It is demonstrated that vinflunine is well tolerated and is definitively active against a range of experimental animal tumor models, with definite superiority over vinorelbine being shown in each tumor model evaluated.
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia
Profound, Non-Opioid Analgesia Produced by the High-Efficacy 5-HT1A Agonist F 13640 in the Formalin Model of Tonic Nociceptive Pain
The results help to establish large-magnitude 5-HT1A receptor activation as a new molecular mechanism of profound, central analgesia and suggest that F 13640 may be particularly effective against pain arising from severe tonic nociceptive stimulation.
F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential.
- W. Koek, J. Patoiseau, F. Colpaert
- Biology, PsychologyThe Journal of pharmacology and experimental…
- 1 October 1998
F 11440, shown here to be a potent, selective, high efficacy 5-HT1A receptor agonist, appears to have the potential to exert marked anxiolytic and antidepressant activity in humans.
Pharmacological studies on zymosan inflammation in rats and mice. 1: Zymosan-induced paw oedema in rats and mice.
F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine.
- G. John, P. Pauwels, F. Colpaert
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 July 1999
F 11356 is a selective, high-potency agonist at 5-HT1B/1D receptors, which distinguishes itself from tryptamine and derivatives in exerting high intrinsic activity at these receptors in vascular and neuronal models relevant to migraine.
Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats
Cutaneously applied erythromycin base reduces various types of inflammatory reactions in mouse ear.
Results suggest some participation of an anti-inflammatory mechanism in the clinical effectiveness of cutaneously applied erythromycin base in some forms of acne.