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A Randomized, Controlled, Double-Blind Trial of Patient-Controlled Sedation with Propofol/Remifentanil Versus Midazolam/Fentanyl for Colonoscopy
BACKGROUND:Patient-controlled sedation (PCS) with propofol has been advocated as a method for dealing with the narrow therapeutic window for moderate sedation, but previous studies have methodologicExpand
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Iterative reconstruction of fluorine-18 SPECT using geometric point response correction.
This article demonstrates resolution recovery in 18F SPECT image reconstruction by using an iterative algorithm that corrects for the system geometric response. Expand
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Guidelines for the use of local anesthesia in office-based dermatologic surgery.
There are an increasing number and variety of dermatologic surgical procedures performed safely in the office setting. This evidence-based guideline addresses important clinical questions that ariseExpand
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Halothane, an inhalational anesthetic agent, increases folding stability of serum albumin.
Inhalational anesthetic agents are known to alter protein function, but the nature of the interactions underlying these effects remains poorly understood. We have used differential scanningExpand
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Cooperative binding of inhaled anesthetics and ATP to firefly luciferase
Firefly luciferase is considered a reasonable model of in vivo anesthetic targets despite being destabilized by anesthetics, as reflected by differential scanning calorimetry (DSC). We examined theExpand
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New bound for the first case of Fermat’s last theorem
We present an improvement to Gunderson's function, which gives a lower bound for the exponent in a possible counterexample to the first case of Fermat's "Last Theorem," assuming that the generalizedExpand
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Transients in orientation of a fluorescent cross-bridge probe following photolysis of caged nucleotides in skeletal muscle fibres.
In muscle fibres labelled with iodoacetamidotetramethylrhodamine at Cys707 of the myosin heavy chain, the probes have been reported to change orientation when the fibre is activated, relaxed or putExpand
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Bound volatile general anesthetics alter both local protein dynamics and global protein stability.
BACKGROUND Recent studies have demonstrated that volatile general anesthetic agents such as halothane and isoflurane may bind to discrete sites on protein targets. In the case of bovine serumExpand
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Differential halothane binding and effects on serum albumin and myoglobin.
To understand further the weak molecular interactions between inhaled anesthetics and proteins, we studied the character and dynamic consequences of halothane binding to bovine serum albumin (BSA)Expand
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Steric hindrance is not required for n-alkanol cutoff in soluble proteins.
A loss of potency as one ascends a homologous series of compounds (cutoff effect) is often used to map the dimensions of binding sites on a protein target. The implicit assumption of steric hindranceExpand
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