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Structural biology of proline catabolism
  • J. Tanner
  • Biology, Medicine
  • Amino Acids
  • 28 March 2008
The proline catabolic enzymes proline dehydrogenase and Δ1-pyrroline-5-carboxylate dehydrogenase catalyze the 4-electron oxidation of proline to glutamate. These enzymes play important roles inExpand
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Flavin reductase P: structure of a dimeric enzyme that reduces flavin.
We report the structure of an NADPH:FMN oxidoreductase (flavin reductase P) that is involved in bioluminescence by providing reduced FMN to luciferase. The 1.8 A crystal structure of flavin reductaseExpand
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Structure and Kinetics of Monofunctional Proline Dehydrogenase from Thermus thermophilus*
Proline dehydrogenase (PRODH) and Δ1-pyrroline-5-carboxylate dehydrogenase (P5CDH) catalyze the two-step oxidation of proline to glutamate. They are distinct monofunctional enzymes in all eukaryotesExpand
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Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein
The PutA flavoprotein from Escherichia coli plays multiple roles in proline catabolism by functioning as a membrane-associated bi-functional enzyme and a transcriptional repressor of prolineExpand
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High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase.
  • J. Jenkins, J. Tanner
  • Biology, Medicine
  • Acta crystallographica. Section D, Biological…
  • 1 March 2006
GAPDH (D-glyceraldehyde-3-phosphate dehydrogenase) is a multifunctional protein that is a target for the design of antitrypanosomatid and anti-apoptosis drugs. Here, the first high-resolution (1.75Expand
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X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability
Retroviral capsids in their native form Capsid proteins of retroviruses form protective lattices around viral RNA molecules. The precise molecular details of how individual, full-length capsidExpand
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Determinants of enzyme thermostability observed in the molecular structure of Thermus aquaticus D-glyceraldehyde-3-phosphate dehydrogenase at 25 Angstroms Resolution.
The crystal structure of holo D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from the extreme thermophile Thermus aquaticus has been solved at 2.5 Angstroms resolution. To study the determinantsExpand
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Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors.
Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the flavin-dependent oxidation of proline to Delta(1)-pyrroline-5-carboxylate. Here we present a structure-based study ofExpand
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Tanner-Whitehouse bone age reference values for North American children.
On the basis of 1090 x-ray films from 225 boys and 225 girls ages 8 to 16 years-participants in the Project Heartbeat longitudinal study who were living in a generally above-average incomeExpand
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The biological buffer bicarbonate/CO2 potentiates H2O2-mediated inactivation of protein tyrosine phosphatases.
Hydrogen peroxide is a cell signaling agent that inactivates protein tyrosine phosphatases (PTPs) via oxidation of their catalytic cysteine residue. PTPs are inactivated rapidly duringExpand
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