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The Transcriptome Profile of Human Embryonic Stem Cells as Defined by SAGE
TLDR
The overlapping similarities and differences in gene expression profiles of human and mouse ES cells provide a foundation for a detailed and concerted dissection of the molecular and cellular mechanisms governing their pluripotency, directed differentiation into specific cell types, and extended ability for self‐renewal. Expand
Human Wharton’s Jelly Stem Cells Have Unique Transcriptome Profiles Compared to Human Embryonic Stem Cells and Other Mesenchymal Stem Cells
TLDR
The ability to modulate immune responses makes hWJSCs an important compatible stem cell source for transplantation therapy in allogeneic settings without immunorejection and provides a foundation for future functional studies where the exact mechanisms of these unique properties of hW JSCs can be confirmed. Expand
Prox1 Is a Novel Coregulator of Ff1b and Is Involved in the Embryonic Development of the Zebra Fish Interrenal Primordium
TLDR
It is proposed that during the course of interrenal organogenesis, Prox1 functions as a tissue-specific coregulator of Ff1b and that the subsequent inhibition of F f1b activity, after its initial roles in the specification of interRenal primordium, is critical for the maturation of the interrennal organ. Expand
A Three Dimensional Anchorage Independent In Vitro System for the Prolonged Growth of Embryoid Bodies to Study Cancer Cell Behaviour and Anticancer Agents
TLDR
A three dimensional anchorage independent in vitro protocol for the prolonged growth of human embryoid bodies (EBs) up to 90 days which can be used to test pluripotency of potential human embryonic and induced pluripotent stem cell lines (hESC, hiPSC), and is an experimental humanized platform to study cancer cell behavior. Expand
Cloning, genomic organization, and expression analysis of zebrafish nuclear receptor coactivator, TIF2.
TLDR
The availability of TIF2 cDNA will allow the analysis of its functional roles in mediating the actions of TRs in various aspects of zebrafish developmental biology. Expand
P60. Functional analysis of stem cell-specific long non-coding RNAs in human embryonic carcinoma cell line NCCIT
TLDR
RNAi knockdown of HEST097 and HEST147 in hECC cell line NCCIT produced minor morphological changes and no overt signs of differentiation despite downregulation of NANOG, which may point towards a role in which the stability of a long non-coding RNA may affect expression of a neighbouring transcript on its chromosome location. Expand
P62. Transcriptome analysis of human Wharton’s jelly stem cells compared to human bone-marrow mesenchymal stem cells for suitability in therapeutic use
TLDR
HWJSCs merit further study as a more suitable alternative to ESCs in stem cell therapy compared to hBMMSCs, and are shown to show significant advantages against ESCs and MSCs due to their behaviour in anti-tumour formation and immune modulatory activity in prospective stem cell treatment. Expand