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The role of non-covalent interactions in anticancer drug loading and kinetic stability of polymeric micelles.
Among all the polymers synthesized in this study, 1b with 8 acid/urea groups in the random form had the optimum properties, indicating that 1b micelles may be a promising carrier for delivery of anticancer drugs that contain amine groups. Expand
The efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus neoformans for the treatment of meningitis.
CG(3)R(6)TAT nanoparticles can be a promising antimicrobial agent for treatment of brain infections caused by C. neoformans, and crossed the BBB and suppressed the yeast growth in the brain tissues with similar efficiency as amphotericin B did. Expand
Synthesis of a family of amphiphilic glycopolymers via controlled ring-opening polymerization of functionalized cyclic carbonates and their application in drug delivery.
The synthesis of a family of amphiphilic block glycopolymers containing d glucose, d galactose and d mannose via metal-free organocatalyzed ring-opening polymerization of functional cyclic carbonates generating narrowly dispersed products of controlled molecular weight and end-group fidelity is reported. Expand
Broad-spectrum antimicrobial and biofilm-disrupting hydrogels: stereocomplex-driven supramolecular assemblies.
These hydrogels with hierarchical nanostructures were made with broad-spectrum antimicrobial activities and biofilm-disruption capability have great potential for clinical use in prevention and treatment of various multidrug-resistant infections. Expand
Control of burst release from nanogels via layer by layer assembly.
- J. Tan, Q. Wang, K. Tam
- Materials Science, Medicine
- Journal of controlled release : official journal…
- 24 June 2008
The present study demonstrates a simple and practical way to reduce or minimize high burst release associated with nanoparticulate delivery systems using alternating layers of poly(allylamine hydrochloride) (PAH, cationic) and poly(sodium 4-styrenesulfonate) (PSS, anionic) polyelectrolytes. Expand
Inverse microemulsion polymerization of sterically stabilized polyampholyte microgels.
- B. Ho, B. Tan, J. Tan, K. Tam
- Chemistry, Medicine
- Langmuir : the ACS journal of surfaces and…
- 27 June 2008
The microgel exhibited thermal-responsive properties at high pH, which is dictated by the lower critical solution temperature of PDMA, and an empirical relationship describing the PMAA composition and IEP was proposed, where the IEP decreased with increasing PMAA content. Expand
Biodegradable nanostructures with selective lysis of microbial membranes.
It is demonstrated that the nanoparticles disrupt microbial walls/membranes selectively and efficiently, thus inhibiting the growth of Gram-positive bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and fungi, without inducing significant haemolysis over a wide range of concentrations. Expand
Hydrogen bonding-enhanced micelle assemblies for drug delivery.
Ring-opening polymerization (ROP) of functionalized cyclic carbonates derived from 2,2-bis(methylol)propionic acid (bis-MPA) allows for incorporation of H-bonding urea-functional groups into block… Expand
The effect of kinetic stability on biodistribution and anti-tumor efficacy of drug-loaded biodegradable polymeric micelles.
The 5K PEG mixed micelles with sizes below 100 nm and narrow size distribution as well as excellent kinetic stability holds great potential as a delivery carrier for amine group-containing anticancer drugs. Expand