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Role of p38-mitogen-activated protein kinase in spontaneous apoptosis of human neutrophils.
TLDR
It is found that p38-MAPK was constitutively tyrosine phosphorylated and activated during spontaneous apoptosis of neutrophils, and this results suggest that the constitutive phosphorylation and activation of p34-mitogen-activated protein kinase are involved in the program of spontaneous apoptoses in neutrophil. Expand
The effects of macrolides on inflammatory cells.
TLDR
The action of macrolides on neutrophil accumulation, immune complex-mediated production of nitric oxide, mucin production, and the expanded therapeutic role of Macrolides as biological response modifiers are discussed. Expand
Acute cigarette smoke exposure induces apoptosis of alveolar macrophages.
TLDR
It is suggested that acute CS exposure is capable of inducing apoptosis of AMs, and this apoptosis was inhibited by antioxidants such as glutathione, ascorbic acid, and alpha-tocopherol. Expand
Japanese guidelines for adult asthma 2017.
TLDR
Inhaled β2-agonists, aminophylline, corticosteroids, adrenaline, oxygen therapy, and other approaches are used as needed during acute exacerbations, by choosing treatment steps for asthma in accordance with the severity of exacerbations. Expand
A Comparison of the Clinical Features of ANCA-Positive and ANCA-Negative Idiopathic Pulmonary Fibrosis Patients
TLDR
It may be important to measure ANCA when idiopathic PF is diagnosed, because a high titer of ANCA suggests a poor prognosis and the association with microscopic polyangiitis. Expand
Effect of clarithromycin on sputum production and its rheological properties in chronic respiratory tract infections.
TLDR
It is suggested that long-term treatment with CAM reduces the amount of sputum production, probably by inhibiting airway secretions, and increasesSputum elasticity, which is similar to placebo. Expand
Mechanisms of airway remodeling in asthma.
TLDR
The recent knowledge of the mechanisms and clinical implications of airway remodeling in asthma is described and potential targets in the treatment of asthma are described. Expand
Ultrafine carbon black particles stimulate proliferation of human airway epithelium via EGF receptor-mediated signaling pathway.
TLDR
It is suggested that ufCB causes oxidative stress-mediated proliferation of airway epithelium, involving processing of HB-EGF and the concomitant activation of EGF-R and ERK cascade. Expand
Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase.
TLDR
It is demonstrated that infection of ferret airway tissues with influenza virus increases the contractile response of airway smooth muscle to substance P, caused by decreased enkephalinase activity in infected tissues. Expand
Clinical implications of the immunomodulatory effects of macrolides.
TLDR
Together, these anti-inflammatory effects result in improved pulmonary functions and fewer airway infections and further work is needed to characterize the clinical benefits of macrolides in patients with other chronic inflammatory airway diseases. Expand
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