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Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.
TLDR
The findings of this study provide support for the view that changes in the cAMP system in the LC play a role in mediating acute opiate action as well as in underlying the development of opiate tolerance, dependence and/or withdrawal. Expand
Chronic morphine treatment increases cyclic AMP-dependent protein kinase activity in the rat locus coeruleus.
TLDR
It is proposed that the observed increase in cyclic AMP-dependent protein kinase activity in the locus coeruleus contributes to the biochemical basis of opiate addiction. Expand
Receptors for the age of anxiety: pharmacology of the benzodiazepines.
TLDR
Evidence indicates that the benzodiazepines exert their therapeutic effects by interacting with a high-affinity binding site (receptor) in the brain and several naturally occurring compounds, including the purines and nicotinamide, are candidates for this role. Expand
Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus.
TLDR
It is raised the possibility that regulation of tyrosine hydroxylase in the LC represents an adaptive response of LC neurons to antidepressants that mediates some of their therapeutic actions in depression and/or other psychiatric disturbances. Expand
The GABA-ergic system: a locus of benzodiazepine action.
TLDR
How interaction of binding sites for GABA, benzodiazepines (BDZ) , andBDZ is described describes how these compounds are capable of producing a spectrum of activities depends on the mode of interaction. Expand
Regulation of G proteins by chronic morphine in the rat locus coeruleus
TLDR
Investigation in the rat locus coeruleus found that chronic, but not acute, treatment of rats with morphine produced an increase in the level of pertussis toxin-mediated ADP-ribosylation of G proteins in the LC, which may represent part of the changes that underlie opiate addiction in these neurons. Expand
Modulation of Protein Kinase C Translocation by Excitatory and Inhibitory Amino Acids in Primary Cultures of Neurons
TLDR
In primary cultures of neurons from rat cerebral cortex and neostriatum, excitatory amino acids stimulate the translocation of protein kinase C (PKC) from the cytoplasm to the membrane and blockade of γ‐aminobutyric acidA receptors by bicuculline greatly enhances glutamate‐induced PKC translocation. Expand
Phosphorylation of the GABAa/Benzodiazepine Receptor α Subunit by a Receptor‐Associated Protein Kinase
TLDR
Findings raise the possibility that the phosphorylation of the α subunit of the GABAa/ benzodiazepine receptor by a receptor‐associated protein kinase plays a role in modulating the physiological activity of the receptor in vivo. Expand
Effects of continuous diazepam administration on GABAA subunit mRNA in rat brain
TLDR
A specific change in α1 subunit of the GABAA receptor is demonstrated that is associated with a state of altered GABA sensitivity and provide further support for the regional heterogeneity of chronic diazepam effects. Expand
Replacement therapy for inherited enzyme deficiency. Use of purified ceramidetrihexosidase in Fabry's disease.
TLDR
It is indicated that exogenous glucocerebrosidase causes definite decreases in the quantity of accumulated lipid in patients with Gaucher's disease. Expand
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