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Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.
TLDR
Anandamide appears to exhibit the essential criteria required to be classified as a cannabinoid/anandamide receptor agonist and shares similar nonreceptor effects on arachidonic acid and intracellular calcium release as other cannabinoid agonists. Expand
Organic solvent extraction of proteins and peptides from serum as an effective sample preparation for detection and identification of biomarkers by mass spectrometry
A method to extract peptides and low molecular weight proteins from serum under denaturing conditions using acetonitrile containing 0.1% trifluoroacetic acid has been developed. The extractionExpand
Regulation of Transforming Growth Factor β1 by Nitric Oxide
TLDR
Results provide the first evidence that nitrosative stress influences the regulation of TGF-beta1 and raise the possibility that NO production may augment TGF -beta1 activity by modifying a naturally occurring neutralizing peptide. Expand
Enrichment of low-molecular-weight proteins from biofluids for biomarker discovery
TLDR
The advantages afforded by recently introduced methods for prefractionation of serum, as they pertain to the detection and identification of biomarkers, will be discussed. Expand
Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides
TLDR
The interaction between HIV-1 nucleocapsid and d(TG)4 is analyzed in considerable detail using surface plasmon resonance, tryptophan fluorescence quenching, fluorescence anisotropy, isothermal titration calorimetry, and electrospray ionization Fourier transform mass spectrometry. Expand
Improved procedure for direct coupling of carbohydrates to proteins via reductive amination.
TLDR
Improved reaction conditions are reported providing an approximately 500% increase in yield and it is found that addition of 500 mM sodium sulfate improves the coupling efficiency. Expand
Regulation of transforming growth factor beta1 by nitric oxide.
TLDR
Results provide the first evidence that nitrosative stress influences the regulation of TGF-beta1 and raise the possibility that NO production may augment TGF -beta1 activity by modifying a naturally occurring neutralizing peptide. Expand
Facile oxidative decarboxylation of 3,4-dihydroxyphenylacetic acid catalyzed by copper and manganese ions.
TLDR
The substrate and catalyst selectivity of this reaction suggest that this may have physiological relevance in the neurotoxic consequences of manganese and copper to the dopaminergic system in man. Expand
Matrix‐assisted laser desorption/ionization mass spectrometry reveals decreased calcylcin expression in small cell lung cancer
TLDR
Proteomic profiles obtained from bronchoscopic biopsy samples via MALDI MS distinguish cancerous epithelium from normal lung tissue and between NSCLCs and SCLCs. Expand
Direct identification of nonreducing GlcNAc residues on N-glycans of glycoproteins using a novel chemoenzymatic method.
TLDR
It is reported herein that the modified sugar, C2 keto galactose, can be transferred to free GlcNAc residues on N-linked glycoproteins, such as ovalbumin or asialo-agalacto IgG1, thereby assisting in the glycotargeting of drugs to the site of action or used as biological probes. Expand
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