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Mutations in the Na+/K+-ATPase α3 Gene ATP1A3 Are Associated with Rapid-Onset Dystonia Parkinsonism
TLDR
Functional studies and structural analysis of the protein suggest that six missense mutations in the gene for the Na+/K+ -ATPase alpha3 subunit (ATP1A3) impair enzyme activity or stability in RDP, and implicates the Na-K+ pump, a crucial protein responsible for the electrochemical gradient across the cell membrane, in dystonia and parkinsonism.
Plasma Membrane Ca2+-ATPase Isoform 2a Is the PMCA of Hair Bundles
TLDR
The data suggest that hair cells control plasma membrane Ca2+-pumping activity by targeting specific PMCA isozymes to distinct subcellular locations, which may be essential for normal hair cell function.
Plasma Membrane Ca2+ Pump in Rat Brain
TLDR
The distinct patterns of expression of the PMCA isoforms in brain suggest that some of them play a special role in intracellular Ca regulation.
Intestinal calcium transport and calcium extrusion processes at the basolateral membrane.
TLDR
Attention in this report is given to the transcellular models of Ca2+ absorption and, more specifically, theCa2+ extrusion events occurring at the basolateral membrane, which include the operation of an ATP-dependent Ca2-dependent pump and a Na+/Ca2- exchanger.
Identification of a peptide inhibitor of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.
TLDR
It is deduced that only inside-out sarcolemmal vesicles participate in the usual Na(+)-Ca2+ exchange assay, which contrasts with the common assumption that both inside- out and right-side-out vesicle exhibit exchange activity.
The Plasma Membrane Calcium Pump Displays Memory of Past Calcium Spikes
TLDR
The memory effect observed in PMCA2b and 4b will allow cells expressing either of them to remove Ca2+ more quickly in subsequent spikes after an initial activating spike, and is due to calmodulin remaining bound to the enzyme during the period at low Ca2+.
Purified (Ca2+-Mg2+)-ATPase of the erythrocyte membrane. Reconstitution and effect of calmodulin and phospholipids.
TLDR
The purified and the reconstituted forms of the enzyme displayed the properties expected of the intact Ca2+ pump; they had an appropriate (Ca2+-Mg2+)-ATPase activity which displayed a relatively low affinity for Ca2+.
Multiple divergent mRNAs code for a single human calmodulin.
TLDR
The results indicate that the human genome contains at least three divergent CaM genes that are under selective pressure to encode an identical protein while maintaining maximally divergent nucleotide sequences.
Plasma Membrane Ca2+ Pump Isoforms 2a and 2b Are Unusually Responsive to Calmodulin and Ca2+ *
TLDR
Experiments designed to determine the source of the higher apparent Ca2+ affinity of rPMCA2b showed that it came from the properties of the carboxyl terminus, rather than from any difference in the catalytic core.
Delayed activation of the plasma membrane calcium pump by a sudden increase in Ca2+: fast pumps reside in fast cells.
TLDR
It is found that different PMCAs are activated by Ca(2+) at different rates, PMCA 3f and 2a being the fastest, and 4b the slowest, and the results suggest that the type of PMCA expressed will correspond with the speed of Ca( 2+) signals in the cell.
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