Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage.
Both high DNA uracil levels and elevated micronucleus frequency (a measure of chromosome breaks) are reversed by folate administration, which could contribute to the increased risk of cancer and cognitive defects associated with folate deficiency in humans.
In vivo rodent erythrocyte micronucleus assay.
- M. Hayashi, R. Tice, H. Shimada
- Medicine, BiologyMutation research
- 1 June 1994
The induction of micronuclei as a measure of genotoxicity. A report of the U.S. Environmental Protection Agency Gene-Tox Program.
- J. Heddle, M. Hite, M. Salamone
- BiologyMutation research
- 1 September 1983
Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythrocytes.
- J. T. Macgregor, J. Heddle, D. Wild
- BiologyMutation research
- 1 October 1987
Micronuclei as an index of cytogenetic damage: Past, present, and future
- J. Heddle, M. Cimino, J. T. Macgregor
- EconomicsEnvironmental and Molecular Mutagenesis
- 1991
After the workshop an effort was made to determine what single protocol would satisfy the requirements set for the micronucleus test by as many regulatory agencies as possible, including the requirements of six regulatory authorities in Canada, the European Economic Community, the Organization for Economic Co‐operation and Development, Japan, and the United States.
Gene expression profiles and genetic damage in benzo(a)pyrene diol epoxide-exposed TK6 cells.
- G. Akerman, B. Rosenzweig, S. Morris
- BiologyMutation research
- 18 May 2004
Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies.
- M. Aardema, J. T. Macgregor
- BiologyMutation research
- 29 January 2002
Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.
- S. Dertinger, S. Phonethepswath, J. T. Macgregor
- BiologyToxicological Sciences
- 1 June 2010
The data show that RETs can serve as an appropriate indicator cell population for 28-day studies and suggest that blood-based genotoxicity endpoints can be effectively incorporated into routine toxicology studies, a strategy that would reduce animal usage while providing valuable genetic toxicity information within the context of other toxicological endpoints.
Micronucleated erythrocyte frequency in peripheral blood of B6C3F1 mice from short‐term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program
- K. Witt, A. Knapton, J. T. Macgregor
- Biology, Environmental ScienceEnvironmental and Molecular Mutagenesis
- 2000
The mouse peripheral blood micronucleus (MN) test has been proposed as a useful adjunct to rodent toxicity tests and has been effectively incorporated as a routine part of overall toxicity testing by the NTP.
In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring
- M. Hayashi, J. T. Macgregor, S. Sutou
- BiologyEnvironmental and Molecular Mutagenesis
- 2000
It was concluded that successful application of automated scoring by both flow cytometry and image analysis had been achieved, and defined criteria that should be met if automated scoring is employed, and it was not felt appropriate to attempt to define specific recommended protocols for automated scoring at the present time.
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