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Lipid profiling by multiple precursor and neutral loss scanning driven by the data-dependent acquisition.
Data-dependent acquisition of MS/MS spectra from lipid precursors enables to emulate the simultaneous acquisition of an unlimited number of precursor and neutral loss scans in a single analysis. ThisExpand
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Top-down lipidomic screens by multivariate analysis of high-resolution survey mass spectra.
Direct profiling of total lipid extracts on a hybrid LTQ Orbitrap mass spectrometer by high-resolution survey spectra clusters species of 11 major lipid classes into 7 groups, which are distinguishedExpand
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nserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans †
Department of Biochemistry, University of E-mail: howard.riezman@unige.ch Department of Chemistry, University of F E-mail: andreas.zumbuehl@unifr.ch National Centre of Competence in Research †Expand
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Mitochondrial Arginase-2 is a cell autonomous regulator of CD8+ T cell function and anti-tumor efficacy.
As sufficient extracellular arginine is crucial for T cell function, depletion of extracellular arginine by elevated Arginase 1 (Arg1) activity has emerged as a hallmark immunosuppressive mechanism.Expand
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1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding.
Ischaemic heart disease and stroke are the most common causes of death worldwide. Anoxia, defined as the lack of oxygen, is commonly seen in both these pathologies and triggers profound metabolic andExpand
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Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish
Oriented cell division is a fundamental mechanism to control asymmetric stem cell division, neural tube elongation and body axis extension, among other processes. During zebrafish gastrulation, whenExpand