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Experimental cardiac hypertrophy induced by isoproterenol in the rat.
TLDR
The IPR-induced cardiomegaly may serve as a model for studying the development of cardiac hypertrophy under various conditions. Expand
Formation of partially phosphorylated phosphorylase in isoproterenol stimulated rat hearts
TLDR
The results strongly suggest that the activity ratio -AMP/+AMP reflects rather the percentage ratio of phosphorylated subunits than that of the activated (partially or totally phosphorylation) phosphorylase molecules. Expand
Adenosine receptors mediate both contractile and relaxant effects of adenosine in main pulmonary artery of guinea pigs
TLDR
It is concluded thatAdenosine causes contraction via dual action on A1 adenosine receptors and on xanthine-resistant sites through dual action at A2a and A1/A2 receptors. Expand
The effect of hypothyroidism on myocardial contractility and sarcoplasmic reticulum function in rats.
TLDR
Function of SR was studied by determining of Ca2+-activated ATPase activity, which was significantly decreased after methimazole treatment, which may be partially responsible for a slower reduction of the free Ca2+) in the surroundings of contractile proteins and thus decrease the rate of relaxation. Expand
Thyroxine-induced cardiomegaly: assessment of nucleic acid, protein content and myosin ATPase of rat heart.
TLDR
Results showed that in hyperthyroid rats, in contrast to some other species, the biochemical mechanism responsible for the enhancement of cardiac contractility is not an increased myosin ATPase. Expand
Alterations of contractility and sarcoplasmic reticulum function of rat heart in experimental hypo- and hyperthyroidism.
TLDR
Changes in Ca2+ transport function of cardiac SR may only partially be responsible for the abnormalities in contraction and relaxation observed in hearts from hypo- and hyperthyroid rats. Expand
Nonspecific membrane effects of CH-103: hydrophobicity, surface activity and membrane fluidity studies in comparison with propranolol and practolol.
TLDR
The results suggest that the physicochemical properties of CH-103, similarly to those of propranolol, are the main determinants of its nonspecific membrane activity. Expand
Positive inotropic effect of the inhibition of cyclic GMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase (PDE2) on guinea pig left atria in eu- and hyperthyroidism.
TLDR
It is concluded that PDE2's inhibition has a significant positive inotropic effect in guinea pig atria and this effect is proven to be augmented in hyperthyroidism. Expand
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