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Trastuzumab causes antibody-dependent cellular cytotoxicity–mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance
In vitro ADCC reaction of human leukocytes was equally strong against breast cancer cells intrinsically sensitive or resistant to trastuzumab or even against a subline of JIMT-1 that was established from xenograft tumors growing despite trastzumab treatment. Expand
Physical Proximity and Functional Association of Glycoprotein 1bα and Protein-disulfide Isomerase on the Platelet Plasma Membrane*
Observations indicated that platelet activation triggered reduction of the active site disulfides of PDI and a conformational change in GP1bα that resulted in exposure of a free thiol(s) on the activated platelet surface. Expand
Physical Proximity and Functional Interplay of the Glycoprotein Ib-IX-V Complex and the Fc Receptor FcγRIIA on the Platelet Plasma Membrane*
Results indicate that GP Ibα and FcγRIIA are co-localized on the platelet membrane and that this association is not random. Expand
ERBB-2 (HER2/neu) gene copy number, p185HER-2 overexpression, and intratumor heterogeneity in human breast cancer.
Results from four human breast cancer cell lines showed the strong possibility of a mechanistic link among p185HER-2 overexpression, ERBB-2 amplification, and high chromosome 17 copy number, and analysis of the primary breast tumor sample showed results similar to the cell lines. Expand
It is concluded that obesity and the consequent estrogen excess decrease the sperm concentration by influencing the hypothalamo-pituitary system. Expand
Molecular modeling of nearly full-length ErbB2 receptor.
Favorable dimerization interactions are predicted for the extracellular, transmembrane, and protein kinase domains in the model of a nearly full-length dimer of ErbB2, which may act in a coordinated fashion in Erb B2 homodimerization, and also in heterodimers of ErBB2 with other members of the ErbA family. Expand
Fluorescence energy transfer measurements on cell surfaces: a critical comparison of steady-state fluorimetric and flow cytometric methods.
The energy transfer efficiency E was measured between fluorescein-conjugated concanavalin A (Con A) and rhodamine-conjugated Con A bound to homogeneous tissue culture cells, the HK22 murine lymphomaExpand
Impaired spermiogenesis as a common finding among professional drivers.
The effect of long-term driving upon spermiogenesis was investigated in 2984 patients, including 281 professional drivers, and there was a higher incidence of impaired fertility in drivers as compared to other professionals. Expand
Attachment of A172 human glioblastoma cells affects calcium signalling: a comparison of image cytometry, flow cytometry, and spectrofluorometry.
The intracellular free calcium concentration ([Ca2+]i) of indo-1 loaded A172 human glioblastoma cells stimulated by platelet-derived growth factor (PDGF) was studied in cell suspensions by flowExpand
AccPbFRET: An ImageJ plugin for semi-automatic, fully corrected analysis of acceptor photobleaching FRET images
AccPbFRET is a user-friendly, efficient ImageJ plugin which allows fully corrected, pixel-wise calculation and detailed, ROI (region of interest)-based analysis of FRET efficiencies in microscopic images. Expand