Trastuzumab causes antibody-dependent cellular cytotoxicity–mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance
- Márk Barok, J. Isola, J. Szöllösi
- Medicine, BiologyMolecular Cancer Therapeutics
- 1 July 2007
In vitro ADCC reaction of human leukocytes was equally strong against breast cancer cells intrinsically sensitive or resistant to trastuzumab or even against a subline of JIMT-1 that was established from xenograft tumors growing despite trastzumab treatment.
ERBB-2 (HER2/neu) gene copy number, p185HER-2 overexpression, and intratumor heterogeneity in human breast cancer.
- J. Szöllösi, M. Balázs, B. Feuerstein, C. Benz, F. Waldman
- BiologyCancer Research
- 15 November 1995
Results from four human breast cancer cell lines showed the strong possibility of a mechanistic link among p185HER-2 overexpression, ERBB-2 amplification, and high chromosome 17 copy number, and analysis of the primary breast tumor sample showed results similar to the cell lines.
EFFECT OF BODY WEIGHT ON TESTOSTERONE/ESTRADIOL RATIO IN OLIGOZOOSPERMIC PATIENTS
- I. Fejes, S. Koloszár, Z. Závaczki, J. Daru, J. Szöllösi, A. Pál
- Medicine, BiologyArchives of andrology
- 1 January 2006
It is concluded that obesity and the consequent estrogen excess decrease the sperm concentration by influencing the hypothalamo-pituitary system.
Molecular modeling of nearly full-length ErbB2 receptor.
- P. Bagossi, Gabor L Horvath, G. Vereb, J. Szöllösi, J. Tözsér
- Biology, ChemistryBiophysical Journal
- 1 February 2005
Favorable dimerization interactions are predicted for the extracellular, transmembrane, and protein kinase domains in the model of a nearly full-length dimer of ErbB2, which may act in a coordinated fashion in Erb B2 homodimerization, and also in heterodimers of ErBB2 with other members of the ErbA family.
Physical association between MHC class I and class II molecules detected on the cell surface by flow cytometric energy transfer.
- J. Szöllösi, S. Damjanovich, F. Brodsky
- Biology, ChemistryJournal of Immunology
- 1 July 1989
Flow cytometric measurements of fluorescence energy transfer using single laser excitation.
- J. Szöllösi, L. Mátyus, S. Damjanovich
- Biology, ChemistryCytometry
- 1 March 1987
Flow cytometric energy transfer measurements between labeled specific sites of cell surface elements have been extended in a simplified form using a flow cytometer equipped with single excitation beam to demonstrate the uniform density of glycoproteins in the plasma membrane of normal and Gross virus leukemic mouse cells of different sizes.
IL-2 and IL-15 receptor alpha-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cells.
- G. Vámosi, A. Bodnár, S. Damjanovich
- BiologyProceedings of the National Academy of Sciences…
- 27 July 2004
This model suggests a direct role for the alpha-subunits, to which no definite function has been assigned so far, in tuning cellular responses to IL-2 or IL-15, which could be the basis of distinct signaling pathways by the two cytokines.
Impaired spermiogenesis as a common finding among professional drivers.
- M. Sas, J. Szöllösi
- MedicineArchives of andrology
The effect of long-term driving upon spermiogenesis was investigated in 2984 patients, including 281 professional drivers, and there was a higher incidence of impaired fertility in drivers as compared to other professionals.
AccPbFRET: An ImageJ plugin for semi-automatic, fully corrected analysis of acceptor photobleaching FRET images
- J. Roszik, J. Szöllösi, G. Vereb
- PhysicsBMC Bioinformatics
- 19 August 2008
AccPbFRET is a user-friendly, efficient ImageJ plugin which allows fully corrected, pixel-wise calculation and detailed, ROI (region of interest)-based analysis of FRET efficiencies in microscopic images.
Attachment of A172 human glioblastoma cells affects calcium signalling: a comparison of image cytometry, flow cytometry, and spectrofluorometry.
- J. Szöllösi, B. Feuerstein, W. Hyun, M. Das, L. Marton
The intracellular free calcium concentration ([Ca2+]i) of indo-1 loaded A172 human glioblastoma cells stimulated by platelet-derived growth factor (PDGF) was studied in cell suspensions by flow…