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  • Influence
Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions
It is shown that activated pyrimidine ribonucleotides can be formed in a short sequence that bypasses free ribose and the nucleobases, and instead proceeds through arabinose amino-oxazoline and anhydronucleoside intermediates. Expand
Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism.
It is shown that precursors of ribonucleotides, amino acids and lipids can all be derived by the reductive homologation of hydrogen cyanide and some of its derivatives, and thus that all the cellular subsystems could have arisen simultaneously through common chemistry. Expand
The Origin of Life--Out of the Blue.
Findings augment key literature results and suggest that hydrogen cyanide--"Blausäure"--was that feedstock for organic synthesis from an environmentally available C1 feedstock molecule. Expand
Prebiotic synthesis of simple sugars by photoredox systems chemistry.
It is shown that these sugars can be formed from hydrogen cyanide by ultraviolet irradiation in the presence of cyanometallates in a remarkable systems chemistry process. Expand
A new plasmid display technology for the in vitro selection of functional phenotype-genotype linked proteins.
The results demonstrate that plasmid display is sufficiently sensitive to select a functional protein from large libraries and that it therefore represents a useful addition to the repertoire of display technologies. Expand
Opinion: Studies on the origin of life — the end of the beginning
This Perspective argues that the authors remain a long way from a full picture and speculates on what pieces of the puzzle are still missing and suggests that they may have nearly finished the first phase: the beginning. Expand
Prebiotic chemistry: a new modus operandi
  • M. Powner, J. Sutherland
  • Chemistry, Medicine
  • Philosophical Transactions of the Royal Society B…
  • 27 October 2011
Here, systems chemistry is exemplified by finding common conditions under which chemical subsystems generate nucleotides and lipids in a compatible and potentially synergistic way, which hint at a post-meteoritic impact origin of life scenario. Expand
The origin of life as a planetary phenomenon
The results indicate that Mars can offer direct evidence for geochemical conditions similar to prebiotic Earth, whose early record has been erased. Expand
Prebiotically plausible oligoribonucleotide ligation facilitated by chemoselective acetylation.
It is shown that the 2'-hydroxyl group of oligoribonucleotide-3'-phosphates can be chemoselectively acetylated in water under prebiotically credible conditions, which allows rapid and efficient template-directed ligation. Expand
Prebiotic Chemistry: A Bioorganic Perspective
1. Scope 2. The Primordial Earth 3. Prebiotic Feedstock Molecules 4. Synthesis of Amino Acids 5. Synthesis of Purines and Chemistry of HCN 6. Synthesis of Pyrimidines 7. Synthesis of Sugars 8.Expand