• Publications
  • Influence
Chronic Hyperinsulinemia in the Fetal Rhesus Monkey: Effects of Physiologic Hyperinsulinemia on Fetal Growth and Composition
TLDR
Data are interpreted as indicating that fetal insulin plays the predominant role in controlling the normal, as well as the augmented, fetal weight characteristic of the human infant of the diabetic mother. Expand
Chronic Hyperinsulinemia in the Fetal Rhesus Monkey: Effects on Hepatic Enzymes Active in Lipogenesis and Carbohydrate Metabolism
TLDR
Fetal hyperinsulinemia with euglycemia increases the activity of enzymes that participate in lipogenesis, decreases some of those controlling gluconeogenesis, and has no effect on the enzymes of glycolysis. Expand
Increased erythropoiesis and elevated erythropoietin in infants born to diabetic mothers and in hyperinsulinemic rhesus fetuses.
TLDR
The mechanism for the increased plasma Ep associated with hyperinsulinemia in the fetus is unexplained but may be mediated by fetal hypoxia. Expand
Chronic Hyperinsulinemia in the Fetal Rhesus Monkey: Effects on Fetal Growth and Composition
TLDR
Based on the similar DNA concentrations and protein/DNA ratios observed in hyperinsulinemic and control groups, the hepatomegaly appears to be the result of insulin-stimulated hyperplasia and not of hypertrophy. Expand
Effects of chronic hyperinsulinaemia on hepatic enzymes involved in lipogenesis and carbohydrate metabolism in the young rat.
TLDR
Chronic (6 days) hyperinsulinaemia in young rats produced lower blood glucose concentrations and augmented body- and liver-weight gain and increased hepatic activities of citrate-cleavage enzyme, 'malic' enzyme and high-substrate pyruvate kinase, and decreased glucose 6-phosphatase. Expand
Somatomedins and insulin in diabetic pregnancies: effects on fetal macrosomia in the human and rhesus monkey.
TLDR
Since fetal SM levels in the humans and monkeys were not significantly different in the two groups, the data suggest that insulin plays the predominant role in stimulating human and subhuman primate excess fetal weight gain of the infant of the diabetic mother during the latter part of gestation. Expand
Glucose kinetics in nondiabetic and diabetic women during the third trimester of pregnancy.
TLDR
In the basal state after an overnight fast, both nondiabetic and diabetic patients accelerated their glucose turnover rate during pregnancy to provide for increased maternal and fetoplacental metabolic requirements, and in the diabetic subjects the nearly normal plasma glucose and insulin concentrations and other metabolic parameters suggested good metabolic control during pregnancy. Expand
Glucose kinetics in infants of diabetic mothers.
TLDR
Glucose kinetic studies were performed to define the glucose turnover rate with 78% enriched D-[U-13C] glucose by the prime constant infusion technique at less than or equal to 6 hours of age in nine infants of diabetic mothers at term, supporting the importance of good control of the diabetic state in the pregnant woman to minimize or prevent neonatal hypoglycemia. Expand
Plasma catecholamine concentrations of newborn piglets in thermoneutral and cold environments.
TLDR
It is concluded that plasma norepinephrine, but not epinephrine, is increased in newborn piglets during environmental cold stress and that the changes in nore Pinephrine concentrations are related to body core hypothermia. Expand
Chronic hyperinsulinemia in the fetal rhesus monkey: effects of physiologic hyperinsulinemia on fetal substrates, hormones, and hepatic enzymes.
TLDR
Fetal rhesus monkeys provides an opportunity to study the metabolic effects of hyperinsulinemia separate from those of hyperglycemia on the primate fetus, making it a useful model for the study of fetal pathologic conditions in diabetic pregnancies. Expand
...
1
2
3
4
5
...