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Chicken STING Mediates Activation of the IFN Gene Independently of the RIG-I Gene
TLDR
Results indicated that chSTING is an important regulator of chicken innate immune signaling and might be involved in the MDA5 signaling pathway in chicken cells, and these results help with understanding the biological role of STING in innate immunity during evolution. Expand
Characterization and determination of holin protein of Streptococcus suis bacteriophage SMP in heterologous host
TLDR
The results suggest that HolSMP is the holin protein of phage SMP and a two-step lysis system exists in SMP. Expand
Muscovy duck retinoic acid-induced gene I (MdRIG-I) functions in innate immunity against H9N2 avian influenza viruses (AIV) infections.
TLDR
It is found that RIG-I expression in brain, spleen, lung and bursa were up-regulated in ducks challenged with H9N2 avian influenza virus, whose six internal genes were closely related to the H7N9 and H10N8 AIV. Expand
IRF7 Is Involved in Both STING and MAVS Mediating IFN-β Signaling in IRF3-Lacking Chickens
TLDR
It is confirmed that although IRF3 is missing in chickens, they employ IRF7 to reconstitute corresponding IFN signaling to respond to both DNA and RNA viral infections and uncovered a mechanism of chIRF7 activation by chSTING. Expand
Functional analysis of c-di-AMP phosphodiesterase, GdpP, in Streptococcus suis serotype 2.
TLDR
A significant contribution of GdpP and its substrate (c-di-AMP) to the biology and virulence of SS2 was revealed and significantly reduced expression of the known virulence genes cps2, sly, fpbs, mrp, ef and gdh were indicated in the gdpP mutant. Expand
A Phage Lysin Fused to a Cell-Penetrating Peptide Kills Intracellular Methicillin-Resistant Staphylococcus aureus in Keratinocytes and Has Potential as a Treatment for Skin Infections in Mice
TLDR
CPTat-JDlys was able to combat MRSA-induced murine skin infections and, consequently, expedite the healing of cutaneous abscesses and suggest that the novel antimicrobial CPP- JDlys may be a worthwhile candidate as a treatment for skin and skin structure infections caused by MRSA. Expand
Chicken TBK1 interacts with STING and is involved in IFN-β signaling regulation.
TLDR
It is concluded that chTBK1 is involved in chSTING-triggered IFN-β signaling in chicken cells through the generation of various ch TBK1 mutant forms and through endogenous Co-IP and LC-MS/MS. Expand
Two myeloid differentiation factor 88 (MyD88) isoforms identified in ducks.
TLDR
The results verify the existence of a MyD 88-dependent signaling pathway in ducks and contribute to understanding the potential role of MyD88s in the innate immune response. Expand
Clustered, regularly interspaced short palindromic repeat (CRISPR) diversity and virulence factor distribution in avian Escherichia coli.
TLDR
It was demonstrated that, with the exception of iucD and aslA, there was no sharp demarcation in the gene distribution between the pathogenic and commensal E. coli strains, while the total number of indicated CRISPR spacers may have a positive correlation with the potential pathogenicity of the E. Escherichia coli. Expand
Chicken DNA virus sensor DDX41 activates IFN‐&bgr; signaling pathway dependent on STING
TLDR
The identification of the first avian DEAD (Asp‐Glu‐Ala‐Asp) box polypeptide 41 (DDX41), an important DNA sensor, in chicken cells is reported, and it is suggested that ch DDX41 is involved in the dsDNA‐ and ds DNA virus‐mediated chDDX 41‐chSTING‐IFN‐&bgr; signaling pathway in chicken Cells. Expand
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