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IL-15 Regulates Homeostasis and Terminal Maturation of NKT Cells
A critical role for IL-15 is revealed in NKT cell survival, which is mediated by Bcl-xL, and effector differentiation, and which is consistent with a role of T-bet in regulating terminal maturation. Expand
Role of TCF/LEF Transcription Factors in Bone Development and Osteogenesis
The structure of T-cell factor/lymphoid enhancer factor (TCF/LEF) and its role in embryonic skeletal development and the crosstalk with related signaling pathways and factors is discussed. Expand
iTRAQ reveals proteomic changes during intestine regeneration in the sea cucumber Apostichopus japonicus.
The results suggest that intestine regeneration constitutes a complex life activity regulated by the cooperation of various biological processes, including cytoskeletal changes, extracellular matrix remodeling and ECM-receptor interactions, protein synthesis, signal recognition and transduction, energy production and conversion, and substance transport and metabolism. Expand
Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers
Sea cucumbers exposed to stressful circumstances eviscerate most internal organs, and then regenerate them rapidly under favorable environments. Reversible protein phosphorylation and acetylation areExpand
Understanding regulation of microRNAs on intestine regeneration in the sea cucumber Apostichopus japonicus using high-throughput sequencing.
High-throughput sequencing applied to investigate alterations of miRNA expression in regenerative intestine compared to normal intestine suggested that these miRNAs play important roles in specific cellular events (cell proliferation, migration, and apoptosis), metabolic regulation, and energy redistribution. Expand
Metabolic responses to intestine regeneration in sea cucumbers Apostichopus japonicus.
Three important genes were differentially expressed to regulate the levels of betaine and N,N-dimethylglycine during intestine regeneration in sea cucumbers, providing an important basis for studying regenerative mechanisms and developing regenerative matrixes. Expand
Time course analysis of immunity-related gene expression in the sea cucumber Apostichopus japonicus during exposure to thermal and hypoxic stress.
This analysis suggests that sea cucumbers demonstrate complex and varied immune responses to different types of stresses, which provides new insights into the adaptive strategies of holothurians in adverse environments. Expand
Leptin Receptor Mediates Bmal1 Regulation of Estrogen Synthesis in Granulosa Cells
  • G. Chu, G. Ma, +4 authors Shiduo Sun
  • Biology, Medicine
  • Animals : an open access journal from MDPI
  • 1 November 2019
Serum estradiol (E2) concentration and the expressions of Bmal1, Lepr, Cyp19a1, and Cyp11a1 genes were found to display well-synchronized circadian rhythms, and it was demonstrated that B mal1 participates in the process by which leptin acts on Lepr to regulate E2 synthesis. Expand
Nanobubbles at the liquid/solid interface studied by atomic force microscopy
Bubbles on the nanometer scale were produced by a special method on solid surfaces. Atomic Force Microscopy (AFM) was used to detect these bubbles. It shows that nanobubbles can be seen clearly inExpand
The regulation mechanism of lncRNAs and mRNAs in sea cucumbers under global climate changes: Defense against thermal and hypoxic stresses
More comprehensive responses were elicited by the combined thermal/hypoxic stress treatment than by individual stresses alone in sea cucumbers, laying the groundwork for future research on molecular mechanisms of echinoderm responses to thermal and hypoxic stress in the context of global climate changes. Expand