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Mitochondrial metabolism of pyruvate is required for its enhancement of cardiac function and energetics.
UNLABELLED Pyruvate augmentation of contractile function and cytosolic free energy of ATP hydrolysis in myocardium could result from pyruvate catabolism in the mitochondria or from increased ratio ofExpand
Antioxidant properties of pyruvate mediate its potentiation of beta-adrenergic inotropism in stunned myocardium.
UNLABELLED This study tested the hypothesis that pyruvate's antioxidant actions, particularly its enhancement of the endogenous glutathione system, mediate its potentiation of beta-adrenergicExpand
Magnesium activated adenosine formation in intact perfused heart: predominance of ecto 5'-nucleotidase during hypermagnesemia.
Magnesium ion-enhanced adenosine formation by 5'-nucleotidase could contribute to the known cardioprotective effects of this clinically used cation. Expand
Cerebral protection during moderate hypothermic circulatory arrest: histopathology and magnetic resonance spectroscopy of brain energetics and intracellular pH in pigs.
The study shows that moderate hypothermic circulatory arrest at 28 degrees C with antegrade brain perfusion duringcirculatory arrest protects the brain but that retrograde cerebral perfusion at 28degree C does not protect the brain. Expand
Effects of ischemia on intracellular rubidium in pig and rat hearts: 87Rb NMR imaging and spectroscopic study
87Rb MR imaging and spectroscopy were used to study the effects of ischemia on the properties of K+ in cardiac tissue and found decreases in LW and increases in Rb+ visibility can be explained by an increase inRb+ mobility caused by displacement of R b+ from anionic binding sites by H+ and changes in intracellular compartmentalization of Rb+. Expand
Contrast agent distribution in microvascular damage of infarcted pig myocardium
It is concluded that microvascular damage may not be sufficient to allow the extravasation of polylysine-Gd-DTPA in infarcted myocardium. Expand
Fructose 1-6 diphosphate prevents intestinal ischemic reperfusion injury and death in rats.
This study evaluates the potential therapeutic value of fructose 1-6 diphosphate on the basis of its ability to enhance anaerobic carbohydrate metabolism during ischemia and to prevent additional tissue injury after reestablishing blood flow by inhibiting the neutrophils to produce oxygen free radicals. Expand
Effects of regional hypoxia and acidosis on Rb(+) uptake and energetics in isolated pig hearts: (87)Rb MRI and (31)P MR spectroscopic study.
The study compared the effects of regional hypoxia and acidosis on Rb(+) uptake and energetics in isolated pig hearts perfused by the Langendorff method and suggests that intracellular acidosis plays a role in the inhibition of Rb (+) uptake during Hypoxia. Expand
Improved brain metabolism with fructose 1-6 diphosphate during insulin-induced hypoglycemic coma.
The data suggest the possibility that, at the doses given in this study, FDP is taken up and used as a metabolic substrate by the brain. Expand
Retrograde cerebral perfusion results in flow distribution abnormalities and neuronal damage. A magnetic resonance imaging and histopathological study in pigs.
ACP preserves uniform blood distribution and normal morphology of brain tissue after prolonged DHCA and Histopathology showed no morphological changes in any area of the brain in the ACP group, whereas varying severity of neuronal damage was observed in different regions of thebrain in the RCP group. Expand