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Aspergillus fumigatus—What Makes the Species a Ubiquitous Human Fungal Pathogen?
TLDR
This brief article focuses on how A. fumigatus is equipped with the features necessary for a ubiquitous pathogen and physical characteristics that allow conidia to reach the distal airways. Expand
Gliotoxin Is a Virulence Factor of Aspergillus fumigatus: gliP Deletion Attenuates Virulence in Mice Immunosuppressed with Hydrocortisone
TLDR
It is confirmed that gliotoxin is an important virulence determinant of A. fumigatus and that the type of immunosuppression regimen used is important to reveal the pathogenic potential of gliot toxin. Expand
Invasive aspergillosis due to Neosartorya udagawae.
TLDR
Fumigati-mimetics with inherent potential for antifungal resistance are agents of IA, and N. udagawae demonstrated relatively higher minimum inhibitory concentrations to various agents, compared with those demonstrated by contemporary A. fumigatus sensu stricto isolates. Expand
Human Polymorphonuclear Leukocytes Inhibit Aspergillus fumigatus Conidial Growth by Lactoferrin-Mediated Iron Depletion1
TLDR
It is shown that human PMN from both normal controls and CGD patients are equipotent at arresting the growth of Aspergillus conidia in vitro, indicating the presence of a reactive oxygen species-independent factor(s). Expand
Agrobacterium tumefaciens-Mediated Transformation of Aspergillus fumigatus: an Efficient Tool for Insertional Mutagenesis and Targeted Gene Disruption
TLDR
ATMT is an efficient tool for transformation, random insertional mutagenesis, and gene disruption in A. fumigatus, and 19 of the 20 randomly chosen albino transformants (95%) were disrupted by homologous recombination. Expand
Invasive fungal disease in autosomal-dominant hyper-IgE syndrome.
TLDR
The epidemiology of invasive mycoses in patients with confirmed STAT3-mutant AD-HIES, due to heterozygous dominant-negative mutations in STAT3, was defined and myeloid function related to fungal susceptibility was evaluated. Expand
Genes Differentially Expressed in Conidia and Hyphae of Aspergillus fumigatus upon Exposure to Human Neutrophils
TLDR
The complex response of the fungus to leukocytes, one of the major host factors involved in antifungal defense, is revealed, and fungal genes that may be involved in establishing or prolonging infections in humans are identified. Expand
Genetic Relatedness versus Biological Compatibility between Aspergillus fumigatus and Related Species
TLDR
These findings underscore the importance of genealogical concordance analysis for species circumscription, as well as for accurate species identification, since misidentification of morphologically similar pathogens with differences in innate drug resistance may be of grave consequences for disease management. Expand
A chitin synthase with a myosin-like motor domain is essential for hyphal growth, appressorium differentiation, and pathogenicity of the maize anthracnose fungus Colletotrichum graminicola.
TLDR
Cl cloning and characterization of three additional chitin synthases encoding class I, III, and V CHS of the maize anthracnose fungus Colletotrichum graminicola are reported on, showing Surprisingly, DeltaCgChsV mutants were able to form dome-shaped hyphopodia that exerted force and showed host cell wall penetration rates comparable with the wild type. Expand
Extrapulmonary Aspergillus infection in patients with CARD9 deficiency.
TLDR
Results show that CARD9 deficiency is the first known inherited or acquired condition that predisposes to extrapulmonary Aspergillus infection with sparing of the lungs, associated with impaired neutrophil recruitment to the site of infection. Expand
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