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The phenobarbital response enhancer module in the human bilirubin UDP‐glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR
The UDP‐glucuronosyltransferase, UGT1A1, is the critical enzyme responsible for detoxification of the potentially neurotoxic bilirubin by conjugating it with glucuronic acid and was effectively activated in mouse primary hepatocytes in response to phenobarbital.
The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics.
Hepatic CYP3A Expression is Attenuated in Obese Mice Fed a High-Fat Diet
- K. Yoshinari, Shunsuke Takagi, Teruyasu Yoshimasa, J. Sugatani, M. Miwa
- Biology, MedicinePharmaceutical Research
- 25 May 2006
High-fat diet-induced changes in energy metabolism, which eventually result in obesity, modulate the hepatic expression profile of P450s, particularly CYP3As, suggesting a clinically important drug–diet interaction.
Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter
- J. Sugatani, Kousuke Mizushima, M. Miwa
- BiologyNaunyn-Schmiedeberg's Archives of Pharmacology
- 3 January 2008
It is indicated that hepatocyte nuclear factor 1α (HNF1α) bound to the proximal promoter motif not only enhances the basal reporter activity of UGT1A1, including the distal (−3570/−3180) and proximal (−165/−1) regions, but also influences the transcriptional regulation of U GT1A 1 by CAR, PXR, GR, and AhR to markedly enhance reporter activities.
Characterization of serum platelet-activating factor (PAF) acetylhydrolase. Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children.
- M. Miwa, T. Miyake, M. Matsumoto
- Medicine, BiologyThe Journal of clinical investigation
- 1 December 1988
Results suggest that deficiency of serum PAF acetylhydrolase might be one of the factors leading to severe respiratory symptoms in asthmatic children.
Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia.
The results indicate that homozygosity and compound heterozygosity for mutations in the UGT1A1 gene promoter (T-3263G and A[TA](7)TAA) and/or exon 1 of the gene (G211A) could explain the hyperbilirubinemia seen in the majority of individuals with Gilbert's syndrome.
Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor, and glucocorticoid receptor.
Changes in the expression of cytochromes P450 and nuclear receptors in the liver of genetically diabetic db/db mice.
- K. Yoshinari, Shunsuke Takagi, J. Sugatani, M. Miwa
- Biology, ChemistryBiological & pharmaceutical bulletin
- 1 August 2006
The results demonstrate that db/db mice and Zucker fatty rats exhibit different expression profiles of P450s and nuclear receptors despite their similar characteristics for obesity and diabetes resulting from a defect in the leptin signaling pathway.
Nuclear distribution of claudin-2 increases cell proliferation in human lung adenocarcinoma cells.