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Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models
Antibody-mediated tumour targeting and nanoparticle-mediated encapsulation can reduce the toxicity of antitumour drugs and improve their efficacy. Here, we describe the performance of aExpand
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Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity
Anti-TNFR2 antibodies induce costimulation of T cells, complete tumor regression, and immune memory in mice and can be combined with anti-PD1. Tampering with TNFR2 Because tumor necrosis factorExpand
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Synergy between EphA2-ILs-DTXp, a Novel EphA2-Targeted Nanoliposomal Taxane, and PD-1 Inhibitors in Preclinical Tumor Models
Combinations of chemotherapy with immunotherapy have seen recent clinical success, including two approvals of anti–PD-1/L1 agents in combination with taxane-based chemotherapy in non–small cell lungExpand
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THE EFFECT OF INHALING CONCENTRATED OXYGEN ON PERFORMANCE DURING REPEATED ANAEROBIC EXERCISE
The objective of the pilot study was to test the effect of inhaling 99.5% oxygen on recovery. The source of concentrated oxygen was O-PUR (Oxyfit). Research subjects completed two thirty-secondExpand
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Dietary supplementation with pecans delays motor neuron pathology in transgenic mice expressing G93A mutant human superoxide dismutase-1.
A growing body of evidence indicates that diet can modulate health in aging to the extent of delaying the manifestation of age-related diseases. Nuts are among the antioxidant-rich foods that haveExpand
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Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and
Alzheimer disease has a complex etiology composed of nutritional and genetic risk factors and predispositions. Moreover, genetic risk factors for cognitive decline may remain latent pendingExpand
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Dietary Supplementation with S-Adenosyl Methionine Delays the Onset of Motor Neuron Pathology in a Murine Model of Amyotrophic Lateral Sclerosis
The full range of causative factors in Amyotrophic lateral sclerosis (ALS) remains elusive, but oxidative stress is recognized as a contributing factor. Mutations in Cu/Zn superoxide dismutase 1Expand
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Abstract 4846: MM-401, a novel anti-TNFR2 antibody that induces T cell co-stimulation, robust anti-tumor activity and immune memory
TNFR2 has been implicated as a novel target for cancer immunotherapy. While TNFR2 has been linked to enhanced suppressive activity of regulatory T cells (Tregs) in auto-immune models, the effect ofExpand
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Abstract 555: A novel human TNFR2 antibody (MM-401) modulates T cell responses in anti-cancer immunity
TNFR2 is an emerging therapeutic target in immuno-oncology. We have previously shown that an agonistic mouse TNFR2 antibody was able to activate CD8 + T cells in vitro and has anti-tumor activity inExpand
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