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Expression of inducible nitric oxide synthase (iNOS/NOS II) in the cochlea of guinea pigs after intratympanical endotoxin-treatment
Since NO is believed to be involved in cochlear physiology, presence of the constitutive isoforms of nitric oxide synthase (NOS), and the target enzyme of NO, soluble guanylyl cyclase (sGC) inExpand
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Serum- and glucocorticoid-inducible kinase 1 (SGK1) mediates glucocorticoid-induced inhibition of insulin secretion.
Glucocorticoid excess predisposes to the development of diabetes, at least in part through impairment of insulin secretion. The underlying mechanism has remained elusive. We show here thatExpand
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  • Open Access
Effects of IKs channel inhibitors in insulin-secreting INS-1 cells
Potassium channels regulate insulin secretion. The closure of KATP channels leads to membrane depolarisation, which triggers Ca2+ influx and stimulates insulin secretion. The subsequent activation ofExpand
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Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells.
Potassium channels regulate insulin secretion. The closure of K(ATP) channels leads to membrane depolarisation, which triggers Ca(2+) influx and stimulates insulin secretion. The subsequentExpand
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The expression and regulation of depolarization-activated K+ channels in the insulin-secreting cell line INS-1
The aim of the present study was to characterize depolarization-activated outward currents in insulin-secreting INS-1 cells and to investigate the role of K+ channels other than the KATP channels inExpand
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Expression of inducible nitric oxide synthase (iNOS/NOS II) in the hydropic cochlea of guinea pigs
Immunohistochemical investigations of the guinea pig cochlea, using a specific antibody to the inducible isoform of NO synthase (iNOS/NOS II), have been performed 3 weeks after closure of the rightExpand
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Modifying quinolone antibiotics yields new anxiolytics
Patients taking fluoroquinolone antibiotics such as norfloxacin exhibit a low incidence of convulsions and anxiety. These side effects probably result from antagonism of the neurotransmitterExpand
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Localisation of the nitric oxide (NO)/cGMP-pathway in the vestibular system of guinea pigs
The exact distribution of nitric oxide-synthases (NOS) in the vestibular system has not been described satisfying yet. Immunostaining, using specific antibodies to the three known NOS-isoforms, toExpand
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Epinephrine-induced hyperpolarization of islet cells without KATP channels.
This study examines the effect of epinephrine, a known physiological inhibitor of insulin secretion, on the membrane potential of pancreatic islet cells from sulfonylurea receptor-1 (ABCC8)-null miceExpand
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  • Open Access
Characterization of the interaction between fenamates and hippocampal neuron GABA(A) receptors.
Fenamate NSAIDs have several central effects, including anti-epileptic and neuroprotective actions. The underlying mechanism(s) of these actions are not presently understood. In this study, theExpand
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