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New β-Caryophyllene-Derived Terpenoids from the Soft Coral Sinularia nanolobata
The cytotoxicity of 1−6 against the growth of a limited panel of cancer cell lines is described and the structures of 1+5 were elucidated on the basis of extensive spectroscopic analyses and by comparison of the spectral data with those of the related metabolites.
Meroditerpenoids from a Formosan soft coral Nephthea chabrolii.
Eight new meroditerpenoid-related metabolites, including one naphthoquinone derivative, chabrolonaphthOquinone B, and four tetraprenyltoluquinone-related compounds, chABrolobenzoquinones E-H, were isolated from the organic extract of a Taiwanese soft coral Nephthea chabroii.
Structural Elucidation and Structure-Anti-inflammatory Activity Relationships of Cembranoids from Cultured Soft Corals Sinularia sandensis and Sinularia flexibilis.
Structural-activity relationship analysis indicated that cembrane-type compounds with one seven-membered lactone moiety at C-1 are potential anti-inflammatory agents.
Sinularin induces DNA damage, G2/M phase arrest, and apoptosis in human hepatocellular carcinoma cells
This study reveals for the first time the anti-HCC activities of sinularin, the active compound isolated from the cultured soft coral Sinularia flexibilis.
11-epi-Sinulariolide Acetate Reduces Cell Migration and Invasion of Human Hepatocellular Carcinoma by Reducing the Activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR Signaling Pathways
It is discovered that 11-epi-SA provided a concentration-dependent inhibitory effect on the migration of human HCC HA22T cells, and suppressed the phosphorylation of ERK1/2 and p38MAPK pathways.
A Soft Coral-Derived Compound, 11-epi-Sinulariolide Acetate Suppresses Inflammatory Response and Bone Destruction in Adjuvant-Induced Arthritis
Based on its attenuation of the expression of proinflammatory proteins and disease progression in AIA rats, the marine-derived compound Ya-s11 may serve as a useful therapeutic agent for the treatment of RA.
Oxygenated cembranoids from a Formosan soft coral Sinularia gibberosa.
Chemical investigation of a Formosan soft coral, Sinularia gibberosa, has led to the isolation of eight oxygenated cembranoids, including seven new compounds, gibberosenes A-G, which were found to be cytotoxic toward a limited panel of cancer cell lines.
Bioactive new withanolides from the cultured soft coral Sinularia brassica.
Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NFκB Signaling Pathway
The results of a set of experiments designed to reveal the underlying mechanism of DT cytotoxic activity against K562 cells suggested that DT can act as a topoisomerase II catalytic inhibitor, unlike the clinical anticancer drug, etoposide, which acts as aTopoisomersase poison.