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Investigation of phase transitions of lipids and lipid mixtures by sensitivity differential scanning calorimetry.
Comparison of the observed transition curves with theoretical curves calculated from the calorimetrically determined phase diagrams supports a literal interpretation of the phase diagrams. Expand
Heat capacity and entropy changes in processes involving proteins.
  • J. Sturtevant
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences…
  • 1 June 1977
Six possible sources of the large heat capacity and entropy changes frequently observed for processes involving proteins are identified and a method is proposed for estimating the magnitudes of the hydrophobic and vibrational contributions. Expand
Biochemical Applications of Differential Scanning Calorimetry
Differential scanning calorimetry (DSC) and the closely related differential thermal analysis (DTA) have been widely employed during the last several decades in the thermodynamic study of processesExpand
High-sensitivity scanning calorimetric study of mixtures of cholesterol with dimyristoyl- and dipalmitoylphosphatidylcholines.
A highly sensitive and stable scanning microcalorimeter is employed in a reinvestigation of the effect of cholesterol on multilamellar suspensions of dimyristoylphosphatidylcholine and DPPC, suggesting the coexistence of two immiscible solid phases. Expand
A thermodynamic study of the trp repressor-operator interaction.
It is suggested that the "tightening of soft internal modes" at and near the polar interface of the complex is more important than previously recognized because previous considerations did not take into account the highly hydrated nature of these polar elements and the concomitant reduction in the degrees of freedom of the water structure. Expand
What makes a protein a protein? Hydrophobic core designs that specify stability and structural properties
This work has repacked the hydrophobic core of the four‐helix‐bundle protein, Rop, with altered packing patterns and various side chain shapes and sizes, which reproduce the structure and native‐like properties of the wild‐type, while increasing the thermal stability. Expand
Significant discrepancies between van't Hoff and calorimetric enthalpies.
The usual assumption in studies of the temperature variation of equilibrium constants for equilibria of the form A+B <-->AB that a plot of ln K vs. 1/T is a straight line with slope equal to -delta HvH/R is not valid in many cases. Expand
Molecular basis of the heat denaturation of photosystem II.
The results suggest that the abnormally sharp A2 peak occurs when the highly oxidizing, sequestered Mn complex (the active site in water oxidation) becomes accessible to the aqueous phase, at elevated temperatures. Expand
Structure of the capsid of Pf3 filamentous phage determined from X-ray fibre diffraction data at 3.1 A resolution.
A molecular model of the Pf3 protein capsid based on the model of Pf1, and refined against the diffraction data using simulated annealing confirms that the two structures are similar, which may reflect a fundamental motif of alpha-helix packing. Expand