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ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23
CD23, the low-affinity immunoglobulin E receptor, is an important modulator of the allergic response and of diseases such as rheumatoid arthritis. The proteolytic release of CD23 from cells isExpand
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CD23: An overlooked regulator of allergic disease
Given the importance of immunoglobulin (Ig) E in mediating type I hypersensitivity, inhibiting IgE production would be a general way of controlling allergic disease. The low-affinity IgE receptorExpand
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Autologous dendritic cell vaccines for non-small-cell lung cancer.
PURPOSE Therapeutic outcomes of definitively treated non-small-cell lung cancer (NSCLC) are unacceptably poor. A wealth of preclinical information, and a modest amount of clinical informationExpand
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Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.
BACKGROUND Asthma, a chronic inflammatory condition defined by episodic shortness of breath with expiratory wheezing and cough, is a serious health concern affecting more than 250 million persons.Expand
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Toll-like Receptor Expression and Activation in Astroglia: Differential Regulation by HIV-1 Tat, gp120, and Morphine
In this study, we aimed to determine whether morphine alone or in combination with HIV-1 Tat or gp120 affects the expression of Toll-like receptors (TLRs) by astrocytes and to assess whether TLRsExpand
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Cutting Edge: Mast Cells Critically Augment Myeloid-Derived Suppressor Cell Activity
Myeloid-derived suppressor cells (MDSCs) are primarily recognized for their immunosuppressive properties in malignant disease. However, their interaction with other innate immune cells and theirExpand
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Unique Cytokine Signature in the Plasma of Patients with Fibromyalgia
Fibromyalgia (FMS) is a chronic pain syndrome with a complex but poorly understood pathogenesis affecting approximately 10 million adults in the United States. The lack of a clear etiology of FMS hasExpand
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IgE , mast cells , basophils , and eosinophils
The prevalence of diseases such as allergic asthma and rhinitis continues to increase in the United States, affecting millions of people. It is wellestablished that allergy contributes to theExpand
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IL-4 and TGF-β1 Counterbalance One Another while Regulating Mast Cell Homeostasis
Mast cell responses can be altered by cytokines, including those secreted by Th2 and regulatory T cells (Treg). Given the important role of mast cells in Th2-mediated inflammation and recentExpand
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Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death
BackgroundFractalkine/CX3CL1 and its cognate receptor CX3CR1 are abundantly expressed in the CNS. Fractalkine is an unusual C-X3-C motif chemokine that is important in neuron-microglialExpand
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