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A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group.
TLDR
A recombinant vaccine based on fusion of the circumsporozoite protein and HBsAg plus a potent adjuvant can protect against experimental challenge with P. falciparum malaria. Expand
Evidence for transmission of Plasmodium vivax among a duffy antigen negative population in Western Kenya.
TLDR
It is shown that a parasite with characteristics of Plasmodium vivax is being transmitted among Duffy blood group-negative inhabitants of Kenya, and positives were found late in the rainy season, when An. Expand
Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites.
TLDR
These results expand published findings demonstrating that immunization by exposure to thousands of mosquitoes carrying radiation-attenuated Pf sporozoites is safe and well tolerated and elicits strain-transcendent protective immunity that persists for at least 42 weeks. Expand
Red cell surface changes and erythrophagocytosis in children with severe plasmodium falciparum anemia.
TLDR
The surface of red cells of children with severe P falciparum anemia is modified by the deposition of IgG and alterations in the levels of complement regulatory proteins, which could contribute to the accelerated destruction ofred cells in these patients by mechanisms such as phagocytosis or complement-mediated lysis. Expand
Protective Immunity Induced with Malaria Vaccine, RTS,S, Is Linked to Plasmodium falciparum Circumsporozoite Protein-Specific CD4+ and CD8+ T Cells Producing IFN-γ1
TLDR
This is the first study demonstrating correlation in a controlled Plasmodia sporozoite challenge study between protection induced by a recombinant malaria vaccine and Ag-specific T cell responses. Expand
Phase I/IIa safety, immunogenicity, and efficacy trial of NYVAC-Pf7, a pox-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria.
TLDR
While antibody responses were generally poor, cellular immune responses were detected in >90% of the volunteers and there was a significant delay in time to parasite patency in the groups of volunteers who received either the low or high dose of vaccine compared with control volunteers. Expand
Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocks
TLDR
The results show that the majority of analysed sequences including several var‐like sequences from the chimpanzee parasite Plasmodium reichenowi can be either directly or indirectly linked together in a single unbroken network, however, the network is highly structured and contains putative subgroups of recombining sequences. Expand
Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum
TLDR
It is reported here that the complement receptor 1 (CR1) is a sialic acid-independent receptor for the invasion of erythrocytes by P. falciparum, and that merozoites interact directly with CR1 on the ERYthrocyte surface and with sCR1-coated microspheres. Expand
Age-related changes in red blood cell complement regulatory proteins and susceptibility to severe malaria.
TLDR
It is concluded that RBC CRP levels vary with age and that the lower levels of these proteins in young children in areas of high transmission, such as western Kenya, may place these children at greater risk of severe malaria-associated anemia than cerebral malaria. Expand
Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine.
TLDR
Further optimization in vaccine composition and/or immunization schedule will be required to induce longer-lasting protective immunity in malaria sporozoite vaccine candidate RTS,S. Expand
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