• Publications
  • Influence
Two forms of electrical resonance at theta frequencies, generated by M‐current, h‐current and persistent Na+ current in rat hippocampal pyramidal cells
TLDR
A novel function for M/KCNQ channels in the brain is suggested: to facilitate neuronal resonance and network oscillations in cortical neurons, thus providing a basis for an oscillation‐based neural code. Expand
Potassium currents in hippocampal pyramidal cells.
  • J. Storm
  • Biology, Medicine
  • Progress in brain research
  • 1990
TLDR
The hippocampal pyramidal cells provide an example of how multiple potassium (K) currents co-exist and function in central mammalian neurones and a transient Ca-dependent K current has been described in certain preparations, but it is not yet clear whether it is distinct from IC and IA. Expand
Temporal integration by a slowly inactivating K+ current in hippocampal neurons
  • J. Storm
  • Biology, Medicine
  • Nature
  • 24 November 1988
TLDR
It is reported that the delayed excitation in rat hippocampal neurons is due to a slowly inactivating potassium current, ID, which enables the cell to integrate separate depolarizing inputs over long times and makes the encoding properties of the cell exceedingly sensitive to the prevailing membrane potential. Expand
Action potential repolarization and a fast after‐hyperpolarization in rat hippocampal pyramidal cells.
  • J. Storm
  • Chemistry, Medicine
  • The Journal of physiology
  • 1 April 1987
TLDR
The repolarization of the action potential, and a fast after‐hyperpolarization, were studied in CA1 pyramidal cells in rat hippocampal slices and it was suggested that two Ca2+‐activated K+ currents were involved: a fast, TEA‐sensitive one (IC) underlying the fast a.h.p., and a slow noradrenaline‐ sensitive one (IAHP), underlying the slow a.p. Expand
Kv7/KCNQ/M and HCN/h, but not KCa2/SK channels, contribute to the somatic medium after‐hyperpolarization and excitability control in CA1 hippocampal pyramidal cells
TLDR
A computational model of a CA1 pyramidal cell predicted that M and h‐channels will generate mAHPs in a voltage‐dependent manner, as indicated by the experiments, and it is concluded that M‐ and h-channels generate the somatic mAHP in hippocampal pyramid cells, with little or no net contribution from SK channels. Expand
Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior
TLDR
It is shown that suppression of the neuronal M current in mice is associated with spontaneous seizures, behavioral hyperactivity and morphological changes in the hippocampus, and M channels are critical determinants of cellular and neuronal network excitability, postnatal brain development and cognitive performance. Expand
An after‐hyperpolarization of medium duration in rat hippocampal pyramidal cells.
  • J. Storm
  • Chemistry, Medicine
  • The Journal of physiology
  • 1 February 1989
TLDR
It was concluded that two currents contribute to the mAHP: IM (a voltage‐gated muscarine‐sensitive K+ current) and IC (a Ca2+‐dependent TEA‐sensitiveK+ current). Expand
Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency.
  • M. Sausbier, H. Hu, +14 authors P. Ruth
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 22 June 2004
TLDR
It is reported that mice lacking BK channels (BK(-/-)) show cerebellar dysfunction in the form of abnormal conditioned eye-blink reflex, abnormal locomotion and pronounced deficiency in motor coordination, which are likely consequences of Cerebellar learning deficiency. Expand
Presynaptic Ca2+-Activated K+ Channels in Glutamatergic Hippocampal Terminals and Their Role in Spike Repolarization and Regulation of Transmitter Release
TLDR
Electrophysiology and immunogold cytochemistry are combined to demonstrate the existence of functional BK channels in presynaptic terminals in the hippocampus and compare their functional roles in somata and terminals of CA3 pyramidal cells, indicating that the functional role of Bk channels depends on their subcellular localization. Expand
Pka mediates the effects of monoamine transmitters on the K+ current underlying the slow spike frequency adaptation in hippocampal neurons
TLDR
It is shown that the modulation of this current by norepinephrine, serotonin, and histamine is mediated by protein kinase A in hippocampal CA1 neurons, and that monoaminergic modulation of neuronal excitability in the mammalian CNS ismediated by protein phosphorylation. Expand
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