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SSR180711, a Novel Selective α7 Nicotinic Receptor Partial Agonist: (II) Efficacy in Experimental Models Predictive of Activity Against Cognitive Symptoms of Schizophrenia
SSR180711 (4-bromophenyl 1,4diazabicyclo(3.2.2) nonane-4-carboxylate, monohydrochloride) is a selective α7 nicotinic receptor (n-AChR) partial agonist. Based on the purported implication of thisExpand
Effects of the cannabinoid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents
BACKGROUND The endocannabinoid system has been implicated in the modulation of emotional processes. METHODS These experiments aimed to investigate the effects of the cannabinoid CB1 receptorExpand
Neurochemical, Electrophysiological and Pharmacological Profiles of the Selective Inhibitor of the Glycine Transporter-1 SSR504734, a Potential New Type of Antipsychotic
Noncompetitive N-methyl-D-aspartate (NMDA) blockers induce schizophrenic-like symptoms in humans, presumably by impairing glutamatergic transmission. Therefore, a compound potentiating thisExpand
Blockade of CRF1 or V1b receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression
Repeated exposure to stress is known to induce structural remodelling and reduction of neurogenesis in the dentate gyrus. Corticotrophin-releasing factor (CRF) and vasopressin (AVP) are keyExpand
Evidence that the Lateral Septum is Involved in the Antidepressant-Like Effects of the Vasopressin V1b Receptor Antagonist, SSR149415
Previous experiments with the first selective nonpeptide vasopressin V1b receptor antagonist SSR149415 ((2S,Expand
Immunohistochemical and neurochemical correlates of learning deficits in aged rats
This study examined whether cholinergic and monoaminergic dysfunctions in the brain could be related to spatial learning capabilities in 26-month-old, as compared to three-month-old, Long-EvansExpand
Differential roles of amygdaloid nuclei in the anxiolytic- and antidepressant-like effects of the V1b receptor antagonist, SSR149415, in rats
RationaleSSR149415 ((2S, 4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide), the first selectiveExpand
Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils
There is a growing interest in the potential anxiolytic- and antidepressant-like effects of compounds that target neurokinin receptors. Since the structure and the pharmacology of the humanExpand
Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia
On native human, rat and mouse glycine transporter-1(GlyT1), SSR130800 behaves as a selective inhibitor with IC50 values of 1.9, 5.3 and 6.8 nM, respectively. It reversibly blocked glycine uptake inExpand
Implication of β3-adrenoceptors in the antidepressant-like effects of amibegron using Adrb3 knockout mice in the chronic mild stress
The involvement of the beta3-adrenoceptor in the antidepressant-like effects of the beta3-adrenoceptor-agonist amibegron is addressed in the chronic mild stress, using adrenergic beta3-receptorExpand
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