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Clinical significance of epithelial-mesenchymal transition
- K. Steinestel, S. Eder, A. Schrader, J. Steinestel
- MedicineClinical and Translational Medicine
- 2 July 2014
A possible correlation between EMT marker expression and patient prognosis is evaluated as well as current therapeutic concepts targeting the EMT process to slow down or prevent metastatic spread of malignant tumors are evaluated.
Expression of AR-V7 in Circulating Tumour Cells Does Not Preclude Response to Next Generation Androgen Deprivation Therapy in Patients with Castration Resistant Prostate Cancer.
Detecting predictive androgen receptor modifications in circulating prostate cancer cells
The ability to determine key resistance-mediating AR modifications in CTCs has the potential to considerably improve prostate cancer treatment.
Heterogeneous Nuclear Ribonucleoprotein K Interacts with Abi-1 at Postsynaptic Sites and Modulates Dendritic Spine Morphology
Heterogeneous nuclear ribonucleoprotein K (hnRNPK), a 65 kDa ssDNA/RNA-binding-protein that is involved in multiple intracellular signaling cascades, is identified as a binding partner of Abi-1 at postsynaptic sites and shows obvious similarities regarding both protein knockdown phenotypes.
Comparative Analysis of AR Variant AR-V567es mRNA Detection Systems Reveals Eminent Variability and Questions the Role as a Clinical Biomarker in Prostate Cancer
- Christof Bernemann, Verena Humberg, +5 authors M. Boegemann
- Biology, MedicineClinical Cancer Research
- 16 April 2019
A comprehensive comparison of different detection approaches for AR-V567es mRNA revealed eminent variability among previously described systems, and demonstrated an overestimation ofAR-V 567es in prostate cancer, presumably due to nonspecific detection of AR-FL mRNA.
The role of histologic subtype, p16INK4a expression, and presence of human papillomavirus DNA in penile squamous cell carcinoma
In contrast to pathological tumour stage, the HR-HPV status, histologic grade, and p16INK4a positivity failed to predict cancer-specific survival; however, its value as an independent prognostic indicator remains to be determined.
Variant histology in bladder cancer: how it should change the management in non-muscle invasive and muscle invasive disease?
- Yvonne Klaile, K. Schlack, M. Boegemann, J. Steinestel, A. Schrader, L. Krabbe
- MedicineTranslational andrology and urology
- 8 January 2016
There is evidence that additional variant histology might prognosticate an impaired prognosis of non-urothelial cancer, and aggressive behavior and often advanced stages at primary presentation are frequently observed in non-UC arguing for radical and sometimes different treatment strategies as compared to pure UC.
Positive surgical margins in nephron-sparing surgery: risk factors and therapeutic consequences
- J. Steinestel, S. Steffens, K. Steinestel, A. Schrader
- MedicineWorld Journal of Surgical Oncology
- 8 August 2014
It is concluded that PSM are generally rare, regardless of the surgical procedure, and are seen more often in connection with an imperative indication for nephron-sparing surgery as well as a central tumor location, and they should lead to close surveillance of the affected kidney and not to immediate intervention.
Influence of serum cholesterol level and statin treatment on prostate cancer aggressiveness
Adjusted and weighed multivariate logistic regression models revealed that preoperative hypercholesterolemia is associated with a diagnosis of high-risk PC which is negatively influenced by statin intake.
Clinical, Serological, and Histopathological Similarities Between Severe COVID-19 and Acute Exacerbation of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD)
The findings indicate that autoimmune mechanisms determine both clinical course and long-term sequelae after SARS-CoV-2 infection, and the presence of autoantibodies might predict adverse clinical course in COVID-19 patients.