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FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4+CD25+ Regulatory T Cells1
TLDR
Clear evidence is provided that in addition to its well-established effects on migration FTY720 leads to a specific down-regulation of proinflammatory signals while simultaneously inducing functional activity of CD4+CD25+ Treg, which may offer a promising new therapeutic strategy for the treatment of IBD. Expand
Short-chain fatty acid (SCFA) uptake into Caco-2 cells by a pH-dependent and carrier mediated transport mechanism
TLDR
The data suggest that the uptake of butyrate in Caco-2 cells occurs via a carrier mediated transport system specific for monocarboxylic acids, which is in accordance with characteristics of the MCT1. Expand
Prospective evaluation of faecal neutrophil‐derived proteins in identifying intestinal inflammation: combination of parameters does not improve diagnostic accuracy of calprotectin
TLDR
This work has shown that the presence of neutrophil‐derived proteins in the blood stream is a markers of inflammatory bowel disease in patients with irritable bowel syndrome and these proteins have the potential to be a biomarker of inflammation. Expand
Nonsteroidal anti‐inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells
TLDR
The aim of this study was to evaluate the effect of NSAIDs (indomethacin, a nonselective COX‐1 and COX-2 inhibitor) on polyamine metabolism in colon cancer cells. Expand
Effects of deoxycholate on human colon cancer cells: apoptosis or proliferation
TLDR
Investigating the effect of deoxycholic acid on proliferation and apoptosis in the colon by exposing colon cancer cells to it in increasing concentrations found it exerts its growth‐related actions in a phorbol ester‐like manner. Expand
Disruption of intestinal barrier function associated with experimental colitis: possible role of mast cells.
TLDR
It is concluded that experimental colitis is associated with severe defects in intestinal transport and barrier functions and that mast cells may contribute to the pathogenesis of these changes. Expand
Butyrate-induced differentiation of Caco-2 cells is mediated by vitamin D receptor.
TLDR
Experiments indicate that the synergistic effect ofbutyrate and 1,25-(OH)2D3 was due to butyrate-induced upregulation of VDR, and imply that butyrates-induced differentiation and p21Waf1/Cip1 expression of Caco-2 cells occur via upregulationof VDR. Expand
Mediation of differentiating effects of Butyrate on the intestinal cell line Caco-2 by transforming growth factor-β1
TLDR
The results directly implicate that the T GF-β isoform TGF-β1 is necessary for butyrate-induced Caco-2 cell differentiation, but other molecular mechanisms may also play a role in the differentiation of this cell line. Expand
Induction of glutathione‐S‐transferase‐pi by short‐chain fatty acids in the intestinal cell line caco‐2
TLDR
The data suggest that the anticancer effect of butyrate in part may be based on the induction of GSTpi activity, resulting in an enhanced detoxification capacity of the gut. Expand
Application of the Glucose Hydrogen Breath Test for the Detection of Bacterial Overgrowth in Patients with Cystic Fibrosis––A Reliable Method?
TLDR
The high rate of CF children with elevated fasting hydrogen breath concentrations indicates that this phenomenon is less a sign of BIO rather than a consequence of global malabsorption and intestinal dysmotility. Expand
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